Saturday 5 March 2016 15:04, UK
Will Tottenham or Arsenal get their title challenge back on track? Will Manchester United maintain their top-four push? Can Bournemouth pile the pressure on Newcastle manager Steve McClaren?
The Premier League returns to action on Saturday lunchtime with the north London derby at White Hart Lane, before six 3pm kick-offs, including Aston Villa's trip to the Etihad Stadium and a buoyant West Ham's visit to Everton.
The Saturday Night Football clash sees Watford host title-chasing Leicester City, while Crystal Palace welcome Liverpool and Manchester United travel to West Brom on Super Sunday.
With all that and more to look forward to, here's what to keep an eye out for...
Will the Foxes continue their impressive run on the road at Watford? (Watford v Leicester City - Saturday, 5.30pm, Sky Sports 1 HD)
By the time Leicester City kick off their Saturday Night Football encounter at Watford, Tottenham could have replaced them at the league's summit on goal difference.
Either way, it will be interesting to see if having to play catch-up affects Claudio Ranieri's side and their unlikely title bid.
The Foxes have stuttered slightly of late, needing a last-gasp goal to beat relegation-threatened Norwich City last weekend, before being held at home by struggling West Bromwich Albion in midweek.
However, both those matches were at the King Power Stadium, whereas Saturday evening's encounter with the Hornets is at Vicarage Road, with Leicester having won 10 and lost just two of their last 17 league games on their travels.
Which north London side gets their title challenge back on track? (Tottenham v Arsenal - Saturday, 12.45pm)
Both clubs suffered defeats in midweek, although Arsenal's capitulation at home to Swansea was arguably the more damaging of the two.
Arsene Wenger's side have created and missed the most big chances in the top flight this season, and can't afford to squander opportunities when they face the league's tightest defence this weekend.
The Gunners have not lost four consecutive games in all competitions since October 2002, but a defeat on Saturday would leave them six points off their bitter rivals and as many as nine off Leicester.
Harry Kane could be the difference on the day. The England forward missed a great chance to equalise at West Ham, but has a good record in London derbies with 13 goals in his last 17 appearances.
Will Everton cool Hammers' top-four talk? (Everton v West Ham - Saturday, 3pm)
Any victory over Tottenham is well received by West Ham fans, but when it delivers a kicking to their rivals' title hopes, it's particularly welcomed.
But aside from Spurs' own ambitions, the midweek win opens up the real possibility of a top-four finish for the Hammers, too.
Saturday's opponents have struggled at home - Everton have won just four of their last 16 league games at Goodison Park - and another victory for Slaven Bilic could lift his side into the Champions League places by 5pm depending on results elsewhere.
Does Manuel Pellegrini rotate against Villa? (Manchester City v Aston Villa - Saturday, 3pm)
The Man City manager blamed a "lack of freshness" for the loss at Liverpool, three days after their Capital One cup triumph over the same opposition at Wembley.
Sergio Aguero, who has not been the most durable member of Pellegrini's squad, played 210 minutes across both matches, and is one of a number of City stars that looked fatigued at Anfield.
The visit of Aston Villa, bottom of the table and winless in their last 13 away league games, could offer Pellegrini the opportunity to rotate ahead of their Champions League second-leg against Dynamo Kiev, especially with Wilfried Bony back from injury.
Will Benik Afobe pile more misery on Newcastle? (Newcastle v Bournemouth - Saturday, 3pm)
Steve McClaren was left ruing a "cruel" defeat to Stoke on Wednesday, while Bournemouth celebrated an impressive 2-0 win over Southampton the day before.
The two sides are now separated by eight points, with Newcastle in the relegation zone on goal difference, and while both clubs spent in January, there's been mixed results so far.
Cherries striker Benik Afobe has four goals in his last seven league games, and his arrival has boosted an attack that lacked cutting edge.
It's an issue that continues to plague Newcastle, especially without Andros Townsend, one of several big-money deals designed to keep them up. His return could prove crucial against a Bournemouth side that's lost just one of their last eight league games away from the Vitality Stadium.
Does Mark Hughes' big-game hoodoo end in west London? (Chelsea v Stoke City - Saturday, 3pm)
Stoke boss Mark Hughes is without a win in his last 34 league trips to Chelsea, Manchester United, Arsenal and Liverpool, a run that includes 30 defeats.
Two months ago the Potters would have been a fashionable tip to take the points at Stamford Bridge, but that was before Chelsea's resurgence under Guus Hiddink really picked up steam.
But Chelsea have won three league games in a row for the first time in almost a year, and have emerged victorious in all seven Premier League meetings between the two clubs in west London.
Will Sunderland's leaky defence hold firm on the south coast? (Southampton v Sunderland - Saturday, 3pm)
Sunderland travel to Southampton on Saturday afternoon struggling near the foot of the table and in desperate need of a positive result to aid their relegation fight.
However, as Sam Allardyce alluded to after the 2-2 draw at home to Crystal Palace in midweek, his side are incapable of keeping clean sheets.
In fact, the Black Cats have managed the joint-fewest shut-outs in the top flight this campaign - three along with Norwich City, who they also share the worst defensive record with having conceded 53 goals so far.
And their weekend trip to the south coast becomes all the more daunting given Sunderland suffered their worst-ever Premier League defeat (0-8) at St Mary's last season.
Will Norwich boost their survival hopes in Swansea? (Swansea City v Norwich City - Saturday, 3pm)
Norwich make the trip to South Wales having not won any of their last eight league games, seven of which ended in defeat.
That dreadful recent run has seen Alex Neil's side slip into the bottom three - albeit on goal difference from Sunderland - making Saturday's match with fellow strugglers Swansea City all the more important.
In fact, if the Canaries can leave with three points this weekend, they will be just three behind the Swans in the race to beat the drop.
Will Palace finally get back to winning ways against the Reds? (Crystal Palace v Liverpool - Sunday, 1.30pm, Sky Sports 1 HD)
Crystal Palace entertain Liverpool in their Super Sunday clash in desperate need of three points, with Alan Pardew's side on a run of 11 top-flight matches without a win.
In fact, the Eagles have picked up just four points since recording their last victory at home to Southampton on December 12, a worrying sequence that has seen them fall from fifth to 14th in the table.
Will United maintain their top-four push at the Baggies? (West Bromwich Albion v Manchester United - Sunday, 4pm, Sky Sports 1 HD)
With Manchester City hosting bottom-of-the-table Aston Villa on Saturday afternoon, the chances are Manchester United will head to The Hawthorns the following day three points behind their arch rivals in the race for a top-four finish.
Louis van Gaal's team have responded well to losing at both Sunderland and FC Midtjylland last month, reeling off four straight wins in three different competitions to breathe new life into their previously stuttering season.
However, despite those improved results, the Red Devils still cannot afford any slip-ups against Albion in their Super Sunday meeting otherwise their hopes of finishing in the top four could be irrevocably damaged.
