Tuesday 25 April 2017 13:36, UK
Heavyweight Week continues on Sky Sports when Manchester City take on Manchester United on Thursday and Tottenham host Arsenal on Nissan Super Sunday.
It's a pivotal time in the season, but whatever happens in the weeks ahead, will any of the key events be as exciting as our top 10 Premier League knockout moments?
In the build-up to Saturday's blockbuster bout between Anthony Joshua and Wladimir Klitschko, we have picked out 10 of the most significant developments in Premier League history and stuck them all together in one video.
Frank Lampard scoring to help Chelsea to a first title in 50 years and Sergio Aguero's late winner against QPR to make Manchester City champions are both there.
So too are the moment Leicester completed the most unlikely of Premier League wins and the time Blackburn pipped Manchester United to the crown.
With six other standout knockout moments, which one have we ranked as the biggest in the history of the Premier League?
Click our video above to see what made it into the top 10 - and which moment we've placed as being greater than all the rest.