Ollie Devoto ruled out after training injury along with Mako Vunipola who misses the match because of family reasons.
Wednesday 19 February 2020 17:34, UK
England head coach Eddie Jones has confirmed Manu Tuilagi is in contention to face Ireland in the Six Nations after recovering from a groin injury.
Tuilagi suffered a "low-grade" groin strain in the 24-17 defeat to France on February 2 and subsequently missed the 13-6 win over Scotland at Murrayfield on February 8.
The Leicester centre has returned to training and is expected to feature when unbeaten Ireland visit Twickenham on Sunday.
"He's good," said Jones, when asked about Tuilagi's progress. "[He] trained fully today so he should be in contention for selection.
"It's good to have a quality player back."
Exeter centre Henry Slade missed both games against France and Scotland after fracturing his ankle in December but could return to the side this weekend.
"Slade trained today so again we've just got to monitor his progress," added Jones, who described Slade's progress as "positive".
Slade's Exeter team mate Ollie Devoto is out of the squad after injuring his back in training.
England will also be without Mako Vunipola, who will miss the match after travelling to Tonga for family reasons, but Jones believes he has enough cover to cope without the Saracens prop.
"He's a quality player but we're luck we're blessed with two outstanding loosehead props in Joe Marler and Ellis Genge," said Jones.
"We can certainly cover the losses of Mako but it is disappointing to lose him."