Gloucester beat an out-of-sorts Harlequins at Kingsholm as the visitors were blanked in a league game for the first time in a decade.
Northampton overcame the loss of injured captain George Furbank to post a statement 30-21 Investec Champions Cup win against the Bulls in Pretoria.
Marcus Smith has signed a new long-term contract that will keep him at Harlequins until at least 2028.
Harlequins said goodbye to Joe Marler and their reputation as one of the Gallagher Premiership's meanest defences as irresistible Bristol stormed The Stoop 48-24.
Harlequins' Joe Marler has brought forward his retirement plans after announcing that Friday night's clash with Bristol at The Stoop will be his final match.
Henry Slade proved his fitness ahead of England's Autumn Nations Series opener but could not prevent Exeter from suffering defeat by Harlequins.
Alex Lozowski booted a penalty with the game's final kick as Saracens claimed a thrilling 37-35 Gallagher Premiership victory over Bristol at Ashton Gate.
Harlequins ended Saracens' 100 per cent record in this season's Gallagher Premiership by defeating their London rivals 17-10.
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