Bristol sent out a major title statement as Pat Lam's men set a new Premiership record in a thumping 54-24 win over Leicester at Welford Road.
Gloucester beat an out-of-sorts Harlequins at Kingsholm as the visitors were blanked in a league game for the first time in a decade.
Marcus Smith has signed a new long-term contract that will keep him at Harlequins until at least 2028.
Rugby has rallied around with messages of support for the family of former England player Tom Voyce, who is believed to have died in a flood-swollen river.
Defending champions Northampton suffered a shock defeat to Gloucester, while Bath returned to top of the Premiership and Sale beat Leicester.
Harlequins said goodbye to Joe Marler and their reputation as one of the Gallagher Premiership's meanest defences as irresistible Bristol stormed The Stoop 48-24.
Sale Sharks and England forward Jonny Hill has received a 10-week ban - with four weeks suspended - after accepting a charge that he abused a spectator.
Henry Slade proved his fitness ahead of England's Autumn Nations Series opener but could not prevent Exeter from suffering defeat by Harlequins.
Six-try Bath powered their way to a bonus-point victory over Sale Sharks to round off the first block of Gallagher Premiership matches in style.
Bristol regained top spot in the Gallagher Premiership as centre Kalaveti Ravouvou scored two tries to underpin a 31-23 victory over champions Northampton at Ashton Gate.
Alex Lozowski booted a penalty with the game's final kick as Saracens claimed a thrilling 37-35 Gallagher Premiership victory over Bristol at Ashton Gate.
Northampton bounced back from their derby disappointment in style as they trounced Sale while Newcastle earned their first Premiership victory in over a year.
Tom Roebuck scored twice as Sale cruised to a thumping 43-10 bonus-point win to condemn Newcastle to a 25th successive Premiership defeat.
Wasps, London Irish and Worcester have each applied for a place in next season's expanded Championship ahead of Sunday's deadline.
England back row Ben Earl scored two tries as Saracens made it three wins from three in the Premiership this season with a 29-14 victory over Exeter.
Bristol moved top of the Gallagher Premiership in bonus-point fashion as they defeated west country rivals Bath 36-26 at the Recreation Ground.
Saracens head of performance Phil Morrow has been blocked from joining the England set-up by Gallagher Premiership clubs.
Wales lock Dafydd Jenkins looks increasingly unlikely to be fit for the autumn internationals.
England fly-half George Ford does not require surgery on his torn thigh muscle and could be fit for autumn internationals.
Bath's impressive start to the Gallagher Premiership season continued with a hard-earned 20-15 victory over Leicester in an error-ridden game.