Barcelona slumped to a 1-0 home defeat by Rayo Vallecano which pushed leaders Real Madrid a step closer to the La Liga title.
Karim Benzema's last-gasp winner sealed Real Madrid's stunning comeback as they recovered from 2-0 down to beat Sevilla 3-2.
Tammy Abraham's penalty more than nine minutes into stoppage time ended Roma’s winless run as Jose Mourinho's scraped a 1-0 victory at 10-man Spezia in Serie A.
Karim Benzema's 83rd-minute goal was enough for Real Madrid to extend their lead at the top of La Liga to nine points with a 1-0 win at Rayo Vallecano.
Valencia shook off the late red card for Jose Gaya to hold La Liga title challengers Sevilla to a 1-1 draw.
Real Madrid were crowned Spanish Super Cup champions after goals from Luka Modric and Karim Benzema earned them a 2-0 win over Athletic Bilbao.
La Liga champions Atletico Madrid were stunned by Granada, losing 2-1 on Wednesday, while Napoli slipped to defeat against Spezia in Serie A.
Serie A leaders Napoli lost for the first time this season as Inter Milan reinvigorated their own title bid with a 3-2 win at the San Siro.
Gareth Bale scores for Real Madrid in their 3-3 draw with Levante, while Tammy Abraham registered two assists in a win for Jose Mourinho's Roma.
RB Leipzig reached the final of the German Cup with a last-gasp 2-1 extra-time victory over Werder Bremen.
Lautaro Martinez's late winner stretched Inter's winning run to eight games, while Cristiano Ronaldo answered his critics with a perfect hat-trick.
Timothy Weah and Jonathan David both scored as Lille won 3-0 at Bordeaux on Wednesday to stay top of the French league ahead of Lyon and PSG.
Real Madrid drew level with Atletico Madrid at the top of La Liga with a 2-0 win over Granada, plus all the latest from Serie A and La Liga.
AC Milan restored their five-point lead at the top of Serie A with a 2-1 win at Sampdoria on Sunday.
Barcelona twice came back from goals down to win 3-2 at Real Betis and cut Real Madrid's lead at the top of La Liga to three points.
Robert Lewandowski scored another double to send Bayern Munich through to the DFB-Pokal quarter-finals as Lazio missed the chance to go second in Serie A.
Karim Benzema scored for the first time in a Madrid derby at the Bernabeu as Real Madrid beat Atletico Madrid 1-0.
Real Madrid moved top of La Liga, until Sunday evening at least, with a 2-1 win at Alaves while Bayern Munich were beaten by Bayer Leverkusen.
Bayern Munich hammered Borussia Dortmund 4-0 at the Allianz Arena, while Real Madrid also hit four against Eibar to keep up with the pace at the top of La Liga.
Romelu Lukaku's goal was not enough for Inter Milan as they missed out on the chance to steal top spot in Serie A from Juventus.