ADO Den Haag and Heerenveen will join Vitesse and Utrecht in the play-offs for the last Europa League spot despite mixed fortunes on the final day.
Former Eredivisie champions FC Twente have been relegated from the league after a thumping 5-0 defeat at Vitesse on Sunday.
Jorrit Hendrix's impressive late strike earned a point for Dutch champions PSV Eindhoven in a 2-2 draw against Roda.
Bryan Linssen scored twice in the second half as Vitesse won 7-0 against 10-man Sparta Rotterdam on Saturday.
PSV hit back from two goals down to win 3-2 at AZ Alkmaar and extend their lead at the top of Eredivisie to 10 points.
PSV Eindhoven maintained their dominance of the Eredivisie with a 5-1 win over NAC Breda on Saturday.
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Ajax celebrated their 118th birthday in memorable fashion with a 5-2 thrashing of Sparta Rotterdam.
Eredivisie leaders PSV Eindhoven suffered a shock 5-0 defeat to struggling Willem II.
Ajax's hopes of winning the Eredivisie title suffered another setback as they were beaten 3-2 at Vitesse Arnhem on Sunday.
AZ Alkmaar kept the pressure on second-placed Ajax by coming from behind to beat the Eredivisie's bottom club Sparta Rotterdam 2-1.
Ajax closed the gap on Eredivisie leaders PSV Eindhoven to five points with a 1-0 win at PEC Zwolle on Sunday.
Steven Bergwijn scored twice as leaders PSV Eindhoven extended their lead to 10 points in a 2-1 comeback victory over bottom side Sparta Rotterdam.
Leaders PSV Eindhoven registered their sixth successive Eredivisie victory as they defeated Excelsior to stay clear of Ajax.
Ajax came from behind to beat NAC Breda 3-1 on Sunday and close the gap on Eredivisie leaders PSV Eindhoven back to seven points.
Ajax beat 10-man Feyenoord 2-0 in De Klassieker as PSV scored a last-gasp winner to maintain their five-point lead at the top of the Eredivisie table.
Brighton winger Soufyan Ahannach has joined Eredivisie side Sparta Rotterdam on a loan until the end of the season.
Mason Mount's second-half strike proved enough as Vitesse Arnhem returned to winning ways against Sparta Rotterdam.
Feyenoord romped a record derby win over Sparta Rotterdam, stunning their rivals with a 7-0 away success.
Ajax closed the gap on Eredivisie leaders PSV to just five points with a hard-fought 3-1 win over struggling Excelsior on Thursday.