New Zealand ran in seven tries to trounce Fiji 47-5, Australia overcame Georgia 40-29, while South Africa beat Portugal 64-21.
Winger Louis Rees-Zammit scored a hat-trick of tries as Wales beat Georgia 43-19 to secure first place in World Cup Pool C.
Fiji fought back from a half-time deficit to edge closer to a place in the Rugby World Cup quarter-finals
Italy face the first of two tough Rugby World Cup chances, Fiji look to clinch a first quarter-final since 2007 and South Africa seek a response.
Eddie Jones' Australia got their World Cup campaign off to a winning start, but remain in need of improvement after a 35-15 win over minnows Georgia.
Duhan van der Merwe led the charge with a double as five-try Scotland overcame another half-time deficit beat Georgia 33-6 at Murrayfield.
All the squads ahead of the 2023 Rugby World Cup in France, which runs from September 8 to October 28.
Georgia pick up a historic Test victory over Wales at the Principality Stadium in Cardiff, as Luka Matkava kicked the winning penalty.