Bordeaux-Bègles face a tough start to the Champions Cup when they host Top 14 leaders Clermont on Sunday.
Glasgow Warriors will attempt to put their poor European away record behind them when they visit Racing 92 on Saturday.
JJ Hanrahan will make his first start for Northampton in Saturday's Champions Cup tie with Scarlets.
We preview each of the five pools in the European Rugby Champions Cup, which gets underway on Friday.
The European Rugby Champions Cup kicks off at Welford Road on Friday night as Leicester entertain Top 14 champions Stade Francais.
The 'Pool of Death' sees four former winners collide, including four-in-a-row chasing Toulon. Can anyone stop them?
Three teams will battle it out for two places with bonus-point wins over struggling Treviso likely to secure a runners-up spot.
Pool 3 is up for grabs as four evenly-matched sides will go head-to-head but will Dan Carter make the difference for Racing?
Clermont Auvergne are favourites to claim top spot but Exeter and Ospreys won't make life easy for them.
Losing bonus points on the road could prove crucial as Saracens, Ulster and Toulouse battle it out in Pool 1.
Will Greenwood gives his pool-by-pool preview for this season's European Rugby Champions Cup.