Exeter Chiefs ran in five tries during an impressive 33-13 home victory over Connacht in European Challenge Cup Pool 2.
London Irish made it two wins from two in the Challenge Cup as they battled past Grenoble 25-15 in France.
Saturday sees four European Rugby Challenge Cup showdowns, with Cardiff, Exeter, Connacht and Gloucester all in action.
Bordeaux-Begles ran in seven tries to thrash London Welsh 52-20 in Pool 4 of the European Rugby Challenge Cup.