Italy will be out for revenge when they host Samoa in their opening end-of-year Test in Ascoli, live on Sky Sports.
Scotland coach Vern Cotter gets his first taste of Murrayfield action when Argentina visit on Saturday.
Wales start their autumn international on Saturday by welcoming Australia to the Millennium Stadium.
Six Nations champions Ireland welcome South Africa to Dublin’s Aviva Stadium on Saturday, live on Sky Sports.
England start their QBE Autumn International series against New Zealand at Twickenham on Saturday, live on Sky Sports.
Jared Payne of Ulster will make his debut for Ireland when they face South Africa at the Aviva Stadium on Saturday.
Uncapped Bath winger Semesa Rokoduguni will make his England debut against New Zealand on Saturday.
Australia coach Michael Cheika has made two changes to his side for Saturday's clash with Wales.
New Zealand have left out Dan Carter out of their squad to face England at Twickenham on Saturday.
New Zealand's Dan Carter says winger Julian Savea is in "red hot" form ahead of Saturday's Test against England.
Ireland hooker Rory Best has been ruled out of Saturday’s Test against South Africa with a calf injury.
South Africa-born full-back Scott Spedding will make his France debut against Fiji on Saturday.
Billy Vunipola says watching New Zealand perform the Haka on Saturday will be a great experience.
Francois Hougaard will start at scrum-half for South Africa against Ireland at the Aviva Stadium on Saturday.
England are set to hand Bath wing Semesa Rokoduguni his debut in Saturday's showdown with New Zealand.
Victor Matfield has hailed Ireland captain Paul O'Connell as "the best player I've played against".
Sky Sports caught up with England captain Chris Robshaw ahead of the Autumn International series at Twickenham.
Sky Sports caught up with England captain Chris Robshaw ahead of their Autumn International series.
Greig Laidlaw will captain Scotland in Saturday’s Test against Argentina at Murrayfield.
Wales head coach Warren Gatland named George North in the centre for Saturday's Test against Australia.