Connacht's Mack Hansen will make his Ireland debut on Saturday vs Wales in the Six Nations, while Bundee Aki starts ahead of Robbie Henshaw.
Wing Josh Adams will make his first Test match appearance at centre when Wales launch their Six Nations title defence against Ireland on Saturday.
Johnny Sexton insists there is "not one ounce of complacency" in Ireland's camp ahead of their Guinness Six Nations opener against depleted Wales.