Fran Sol scored a hat-trick as Willem II thrashed the previously unbeaten Heracles Almelo 5-0 in the Eredivisie.
AZ Alkmaar continued to set a strong early pace in the Eredivisie after overwhelming FC Emmen 4-1 at De Oude Meerdijk.
Ajax were surprised by Heracles as they were held to a 1-1 draw on the opening weekend of the Eredivisie.
ADO Den Haag and Heerenveen will join Vitesse and Utrecht in the play-offs for the last Europa League spot despite mixed fortunes on the final day.
Former Eredivisie champions FC Twente have been relegated from the league after a thumping 5-0 defeat at Vitesse on Sunday.
David Neres scored twice as Ajax moved a step closer to Champions League qualification with a 4-1 win at home to VVV-Venlo.
PSV Eindhoven secured their 24th Eredivisie title after beating Ajax 3-0 on Sunday.
PSV Eindhoven maintained their dominance of the Eredivisie with a 5-1 win over NAC Breda on Saturday.
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Eredivisie leaders PSV Eindhoven returned to winning ways on Saturday evening with a 3-0 home victory over VVV Venlo.
Ajax closed the gap on Eredivisie leaders PSV Eindhoven to five points with a 1-0 win at PEC Zwolle on Sunday.
Steven Bergwijn scored twice as leaders PSV Eindhoven extended their lead to 10 points in a 2-1 comeback victory over bottom side Sparta Rotterdam.
Leaders PSV Eindhoven registered their sixth successive Eredivisie victory as they defeated Excelsior to stay clear of Ajax.
Ajax came from behind to beat NAC Breda 3-1 on Sunday and close the gap on Eredivisie leaders PSV Eindhoven back to seven points.
Ajax dropped two points in their effort to close the gap on leaders PSV Eindhoven as they were held to a goalless draw by Utrecht.
Lukas Gortler was shown a second yellow card for Utrecht after time-wasting, despite having already been substituted.
Robin van Persie returned to action for Feyenoord after 14 years away as a late substitute, but could not find a winner in their 1-1 draw at Utrecht.
Feyenoord romped a record derby win over Sparta Rotterdam, stunning their rivals with a 7-0 away success.
PSV Eindhoven conceded a last-gasp equaliser as FC Groningen fought back to draw 3-3 in the Eredivisie.
Nicolas Isimat-Mirin grabbed a dramatic winner as Eredivisie leaders PSV stretched their winning run to eight with a 1-0 victory at Zwolle.
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