Stefan Thesker scored an injury-time own goal as Eredivisie leaders PSV Eindhoven moved eight points clear with a dramatic 4-3 win over FC Twente.
Hirving Lozano and Jurgen Locadia each scored twice as PSV Eindhoven restored their five-point lead at the top of the Eredivisie.
Kasper Dolberg scored twice as Ajax beat rivals Feyenoord 4-1 in the Eredivisie on Sunday.
Feyenoord missed the chance to go level on points with Eredivisie leaders PSV after being held to a goalless home draw by PEC Zwolle.
Feyenoord won 4-0 at AZ to climb up to second, Ajax beat Heerenveen by the same scoreline while Vitesse and Utrecht drew 1-1.
Jurgen Locadia scored four goals as PSV Eindhoven trounced FC Utrecht 7-1 to climb to the top of the Eredivisie table.
Champions Feyenoord saw their 100 per cent start to the Eredivisie season end with a 1-0 defeat at PSV Eindhoven.
Heerenveen secured a surprise 2-0 home win over 10-man PSV Eindhoven on Sunday.
Feyenoord moved top of the Eredivisie with a 5-0 thumping over Willem II on Sunday afternoon.
FC Utrecht cruised to an opening-night victory in the Eredivisie as they won 3-0 at ADO Den Haag.
Utrecht have qualified for the Europa League after overturning a 3-0 deficit against AZ to triumph on penalties in a dramatic play-off.
AZ Alkmaar took a huge step towards next season's Europa League after beating Utrecht 3-0 at the AFAS Stadion.
AZ Alkmaar will play FC Utrecht in the Eredivisie's Europa League play-off final after they negotiated semi-final ties.
Ajax kept up the pressure on leaders Feyenoord in the race for the Eredivisie title by thrashing Heerenveen.
Steven Berghuis' double salvaged a point for Feyenoord as the Eredivisie leaders were held to a 2-2 at PEC Zwolle on Sunday.
PSV Eindhoven moved up to second place in the Eredivisie after a 2-0 win at Sparta Rotterdam.
PSV Eindhoven beat Vitesse 1-0 to close the gap on second-placed Ajax to a point and move five behind leaders Feyenoord.
ADO Den Haag boosted their hopes of survival in the Eredivisie with a 1-0 home victory against NEC on Saturday.
Mathias Pogba struck the game's only goal as Sparta Rotterdam became the first team this year to beat Feyenoord in the Eredivisie.
Utrecht came from two goals down to win 3-2 at Groningen to record a fourth win in the last five Eredivisie matches.