Who will go No 1? Which quarterback will be taken first? Will there be a surprise selection early?
All these questions will be answered on Thursday night as NFL Commissioner Roger Goodell hosts the opening round of the 2017 Draft, live from Philadelphia.
The Cleveland Browns currently possess the first overall pick, but have talked up the possibility of trading away. Meanwhile, the New England Patriots do not have a selection in the opening two rounds, after securing the services of wide receiver Brandin Cooks in exchange for their first-round pick.
There will be plenty of conjecture, rumour and bargaining, and you can follow it all live, with Sky Sports.
Watch live
Tune in from 1am on Friday April 28 on Sky Sports 2, as Goodell announces each team's opening round selection. Day two begins on Saturday morning, from 12am, also on Sky Sports 2.
Sky Sports Xtra
Follow the second half of the draft, on Saturday night, from 5pm on Sky Sports Xtra, via SkySports.com. Rounds 4-7 will be streamed live, so you can watch all 256 picks live.
Follow the blog
NFL Editor Tom Julian will be following all the action and gauging opinion as the first round announcements are made.
Track all the moves, trades and team selections, as players' stock rise and fall throughout the night. Hear comments from players and pundits as the NFL world reacts to each pick.
@SkySportsNFL
As well as the blog, we will keep you up to date with all the information via our Twitter handle. Follow @SkySportsNFL for all the latest information and reaction, throughout the season.
Let us know who you want your team to sign by tweeting us through the night.
Tune in to the 2017 NFL Draft, live on April 28, from 1am on Sky Sports 2.