Olivier Giroud and Francis Coquelin will be unavailable for Arsenal as they welcome Basel to the Emirates in the Champions League on Wednesday evening.
The France forward is suspended after his red card in the 1-1 draw with Paris Saint-Germain, while midfielder Coquelin picked up a knee injury at the weekend and is set to be out for around three weeks.
The Gunners will be buoyed by their 3-0 victory over Chelsea in the Premier League on Saturday, but Arsene Wenger is wary of the threat Basel pose in Europe.
"They have beaten everybody in England - Man United, Chelsea and Liverpool. They have strong results in Europe," the manager said in a pre-match press conference.
The Swiss club are unbeaten in their last six games in all competitions and drew 1-1 with Ludogorets in their opening Champions League fixture a few weeks ago.
Team news
David Ospina could come back in between the sticks in place of Petr Cech, while Aaron Ramsey, Danny Welbeck, Gabriel Paulista and Per Mertesacker remain sidelined with injury.
Arsenal midfielder Granit Xhaka celebrated his 24th birthday on Tuesday and will mark it with a trip back to his homeland of Switzerland, as well as another competitive meeting with brother and Basel midfielder Taulant Xhaka.
Both are in line to start a few months after they became the first siblings to meet in a European Championships during the summer tournament in France where Taulant represented Albania.
Basel are expected to name a similar side that started against Ludogorets, although they will be without defender Manuel Akanji and midfielder Kevin Bua.
Match stats
This is the first competitive meeting between Arsenal and Basel.
Arsenal have won all four of their previous competitive encounters with Swiss clubs (eight goals scored, one conceded), their last coming in the 2005/06 Champions League group stages (2-1 and 1-0 v Thun).
Basel have lost only one of their 10 Champions League encounters with English clubs (W4 D5) - against Manchester Utd at home in November 2002 (1-3).
Basel are unbeaten away from home against English opposition in the Champions League (W1 D4).
Basel have never failed to score in their 10 Champions League games against English opposition.
Arsenal have lost three of their past 38 home games in the Champions League group stages, winning 29 and drawing six.
Basel are winless in their past five Champions League games (D3 L2), scoring just three goals.
Arsenal have qualified for the Champions League for the 19th consecutive season, only Real Madrid (20) can boast a longer current streak.
Arsenal have made it past the group stages in the past 13 seasons but have been knocked out at the last-16 stage in the past six campaigns. Their solitary Champions League final ended in defeat against Barcelona in 2006.
Seven of the past eight Champions League goals scored by Arsenal have been converted by either Alexis Sanchez (four) or Olivier Giroud (three).
Charlie's prediction
This isn't as easy as some people will think, but the one thing I always say is when Arsenal start quick, they can beat anybody.
Chelsea were poor at the weekend but Arsenal were very, very good, especially the way they started the game, which is when they counter-attack with purpose.
I think the competition for places is very important. Francis Coquelin has done well but his injury will see Granit Xhaka get the chance he deserves, so the squad is in a healthy place, although I'm still not convinced by Alexis Sanchez leading the line.
If Arsenal start quick, I expect another comfortable victory and the game to be done within the hour, but if they fail to do that then Basel can be a stubborn team to break down.
Charlie predicts: 3-0 and Theo Walcott to score first (35/1 with Sky Bet)
Betting
Arsenal are just 30/100 with Sky Bet for the victory this evening, with Basel up against odds of 10/1 to win and 19/4 just to secure a draw.
The Gunners are, however, up against odds of 33/1 to win the Champions League, but even-money to win Group A.
Sanchez heads the first goalscorer betting but is enhanced from 100/30 to 4/1 to net first in Sky Bet's Price Boosts, while Marc Janko is considered the visitors' main threat at 17/2 to break the deadlock.