Watch the opening game of the 2021 NFL season - Dallas Cowboys @ Tampa Bay Buccaneers - live on Sky Sports NFL from 1.20am on Friday morning; And join Neil Reynolds and co for the Sunday night triple-header of NFL action from 5pm, Sunday
Sunday 12 September 2021 18:08, UK
Sky Sports' weekly NFL predictions returns for a new season, with Neil Reynolds and Jeff Reinebold going head to head once again.
As well as hosting Inside The Huddle on Sky Sports NFL every Tuesday at 9pm, the pair will release a weekly audio edition of ITH every Wednesday in which they'll make their picks.
Click on the link below to listen to this week's podcast, as Neil and Jeff look ahead to the opening weekend of the 2021 NFL season and chat Fantasy Football.
Read on below to see Neil and Jeff's Week One predictions...
Sunday, live on Sky Sports NFL, 6pm
NEIL PICKS: Bills
"Pittsburgh's defense, of course, is very good, but Josh Allen was a perfect 6-0 last year against top 10 defenses.
"He's at home, and I can only imagine what the atmosphere is going to be like with Bills Mafia in the building! I think it will drive the Bills on to win."
JEFF PICKS: Bills
"This is going to be an unbelievably physical game. This is going to be a tough Pittsburgh defense coming into town.
"But the Steelers' offensive line is just not ready yet - you could see that in preseason - and so I'm taking the Bills."
Sunday, live on Sky Sports NFL, 9.25pm
NEIL PICKS: Chiefs
"A repeat of the playoff game from last year. This is going to be a cracker.
"I think this is another where Arrowhead Stadium is going to play a big part and the Chiefs are going to put up some points."
JEFF PICKS: Chiefs
"I've still got questions about Cleveland's defense. And if anybody can expose a questionable defense, it's Kansas City - so I'm taking them at home."
Sunday Night Football, live on Sky Sports NFL, Monday, 1.20am
NEIL PICKS: Rams
"Two quarterbacks making their debuts for these teams. One is a little more eagerly awaited than the other - Matthew Stafford for the Rams. I cannot wait to see what he brings to Sean McVay's offense, it could be the final piece in their Super Bowl puzzle.
"Andy Dalton, meanwhile, gets the nod for the Bears, and I still can't quite get my head around that one. Rams to win at home in SoFi Stadium."
JEFF PICKS: Rams
"This is a Rams team that has pushed all of their chips into the middle of the table and have said, 'let's go'. Rams win."
Monday Night Football, live on Sky Sports NFL, Tuesday, 1.15am
NEIL PICKS: Ravens
"There's going to be a lot of attention this year on Jon Gruden, Derek Carr and that entire team. I think their offense is good, but I worry about their defense and I think Baltimore can push them around a bit - Ravens to win on the road."
JEFF PICKS: Ravens
"It's going to be a mad house in that stadium in Las Vegas! But how do you control a crowd? You run the football, pound away at them.
"And the Raiders have got to show me that they're good enough on defense up front, that they've got a firm enough chin, to get into games like this. I don't see it yet, so I'm taking Baltimore."
NEIL PICKS: Buccaneers
"Tom Brady is 14-4 in Week One across his career. He's also a perfect 5-0 against the Cowboys, so I'm going with Tampa Bay at home. I think how they finished last season is how they'll start this one."
JEFF PICKS: Buccaneers
"The Buccaneers have not only kept that Super Bowl team together, but they've actually added to it.
"Dallas will be better than last year - I'm actually really excited to see what [new defensive coordinator] Dan Quinn is able to do with the Dallas defense - but I don't think they're yet at the elite level and so I think Tampa will win."
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