Barcelona let three points slip at Osasuna as a late stunner from Chimy Avila secured a 2-2 draw for the hosts, while Real Madrid were victorious in the Madrid derby.
Leicester were eliminated from the Europa League after suffering an agonising 3-2 defeat to Napoli at the Stadio Diego Armando Maradona.
Leicester have dropped into the Europa Conference League but manager Brendan Rodgers admitted he does not even know what the competition is.
Serie A leaders Napoli lost for the first time this season as Inter Milan reinvigorated their own title bid with a 3-2 win at the San Siro.
Napoli will celebrate the life of Diego Maradona with a specially-designed shirt to be worn by players in the side’s three Serie A games to be played in November.
Moussa Diaby scored twice as Bayer Leverkusen romped to a 4-0 Europa League victory over Real Betis, while Lyon have qualified from Group A after beating Sparta Prague.
Bayern Munich thrashed Bayer Leverkusen 5-1 to reclaim top spot in the Bundesliga, while Juventus continued their winning run by beating Jose Mourinho's Roma.
Goals from Memphis Depay, Luuk de Jong, and Ansu Fati helped ease the pressure on Barcelona head coach Ronald Koeman with a 3-0 win over Levante at the Nou Camp.
Multiple arrests were made following a fight between Leicester City and Napoli fans ahead of their Europa League tie.
Leicester surrendered a two-goal lead in the final 20 minutes as Victor Osimhen's double earned Napoli a 2-2 draw in their thrilling Europa League opener.
Team news and stats ahead of Leicester vs Napoli in the Europa League group stage on Thursday; kick-off 8pm.
Erling Haaland scored two goals as Borussia Dortmund came from behind before beating Bayer Leverkusen 4-3 and Bayern Munich thumped RB Leipzig 4-1.
Lille have been crowned Ligue 1 champions after a 2-0 victory at Angers on the final day of the season
Luis Suarez's 88th-minute winner against Osasuna has left Atletico Madrid on the brink of clinching the La Liga title for only the second time since 1996.
Lazio revived their hopes of Champions League qualification and subjected AC Milan to a second consecutive Serie A defeat as Joaquin Correa scored twice in a 3-0 win.
Atletico Madrid stayed in control of La Liga's title race by beating Huesca 2-0 while Lionel Messi scored twice in Barcelona's win against Getafe.
AC Milan's Franck Kessie scored a last-minute penalty to rescue a 1-1 draw against Udinese, handing Inter the opportunity to stretch their lead in the Serie A title race
Napoli crashed out of the Europa League after failing to overcome a two-goal first-leg deficit against Granada, while AC Milan and Roma progressed to the last 16.
Serie A leaders Milan were stunned 2-0 by Spezia to give Inter the chance to leapfrog them, while Atletico Madrid went eight points clear in La Liga.
Gianluca Mancini's late goal earned hosts Roma a 2-2 draw with Inter which left the visitors three points behind leaders AC Milan in the Serie A title race.