AC Milan extended their lead to six points on Sunday, but were held on home soil in an eight-goal thriller.
Milan continue to set the pace, Lazio drew, Leonardo won his first game at Inter and Juve were thrashed.
The final round of Serie A matches in 2010 produced victories for Napoli and Lazio, but Juventus drew.
AC Milan stretched their lead at the top to six points as Lazio went down 2-1 to Juventus.
Lecce president Pierluigi Semeraro is keeping faith with Luigi De Canio following the defeat by Genoa.
Sampdoria remain in the hunt of Champions League football, while Juventus, Fiorentina and Genoa won.
A decision on Lecce manager Luigi De Canio's future will be made this week after he offered to step down.
Inter Milan returned to winning ways while Lazio failed to take a slice out of AC Milan's lead at the top.
Udinese advanced to the fifth round with a 2-1 win over Lecce, while Genoa triumphed over Vicenza.
Lecce striker Ernesto Chevanton has been given a five-match ban following his sending-off against Sampdoria.
Lazio missed the chance to move back to within a point of AC Milan after they were held at Parma.
Zlatan Ibrahimovic ignored the boos to give AC Milan a deserved 1-0 win over former side Inter Milan.
AC Milan went top of Serie A by beating Palermo as Lazio lost away to Cesena and Inter Milan drew.
Inter Milan clinched a controversial draw at lowly Brescia as Bologna left it late to see off Lecce.
A red card for Francesco Totti shrouded the positive aspects of Roma's 2-0 victory over Lecce.
Serie A leaders Lazio progressed to the fourth round of the Coppa Italia with victory against Portogruaro.
Serie A leaders Lazio made it four wins in a row as Inter, Juventus and Roma were all held.
Lazio reclaimed top spot, while Cagliari's home game with Inter Milan was marred by racist chanting.
Lazio's fine run of form continued on Sunday, while Napoli are also making impressive progress.
Palermo striker Fabrizio Miccoli has admitted he would love to finish his career with Lecce.
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