Grimsby were handed a League Two reality check as Carlisle boosted their automatic promotion push with a 2-0 victory over the FA Cup quarter-finalists at Brunton Park.
Vincent Kompany will return to Man City for the first time as manager with Burnley drawn against his former side in the FA Cup quarter-finals.
League Two club Grimsby became shock FA Cup quarter-finalists as they knocked out Premier League side Southampton with a 2-1 win at St Mary's.
Leaders Leyton Orient remained on course for League Two promotion after an entertaining 2-2 draw with Grimsby Town.
Battling Harrogate held on for a precious point as they secured a goalless Sky Bet League Two draw at Grimsby.
Anthony Glennon headed in a stoppage-time winner as Grimsby came from behind to beat promotion-chasing Northampton 2-1 at Sixfields.
Oli Hawkins was Gillingham’s hero as Neil Harris’ side beat Grimsby 2-1 to move out of the League Two relegation zone.
Colchester United made it five away victories on the spin in League Two with a gutsy 1-0 success over Grimsby Town at Blundell Park.
First-half strikes from John McAtee and George Lloyd put Grimsby on course to a comfortable 3-0 win at Crewe.
Jordan James struck in stoppage time as Birmingham snatched a dramatic 2-2 draw at Blackburn in the FA Cup fourth round. A full round-up of Saturday's games...
Charlie Austin scored on his second debut for Swindon as the Robins climbed back into the play-off places with a thumping 5-0 win over 10-man Grimsby.
Arsenal will face a huge FA Cup fourth-round tie against Manchester City at the Etihad after they beat Oxford United on Monday night.
Grimsby won for only the second time in 10 League Two matches as they earned a 1-0 victory over Stockport.
Salford maintained their Sky Bet League Two promotion push with a comfortable 4-1 win against mid-table Grimsby at Blundell Park.
Grimsby keeper Max Crocombe's stoppage-time own goal earned Harrogate a third straight Sky Bet League Two win following a 3-2 thriller.
Grimsby ended their six-match winless run in League Two with a 2-1 victory over slumping Tranmere at Blundell Park.
Ethan Chislett's second-half strike fired AFC Wimbledon to a 1-0 victory over Grimsby at the Cherry Red Records Stadium.
Manchester City will host Chelsea in an English domestic cup competition again in the FA Cup third round.
Grimsby netted a last-gasp equaliser draw 1-1 with promotion-chasing Stevenage and bring their three-match losing run to an end.
Doncaster produced a cut-throat attacking display to sweep aside Grimsby with a 3-1 win at Blundell Park.