Barcelona once again moved five points clear of title challengers Atletico Madrid after a hard-fought 3-1 victory over Leganes.
Borja Baston salvaged a point for Alaves in a 1-1 draw at Girona on Saturday but the visitors missed the chance to move up to third place in La Liga table.
Real Madrid steadied the ship as a 3-0 win over Leganes put them on the brink of the Copa del Rey quarter-finals.
Jonathan Calleri scored the only goal as Alaves climbed to fifth in La Liga with a 1-0 win at Real Sociedad, while Girona and Getafe drew 1-1 in the day's other game.
Denis Suarez struck twice for Copa del Rey holders Barcelona as they thrashed Cultural Leonesa 4-1 on Wednesday to progress to the last 16 5-1 on aggregate.
Barcelona returned to the top of La Liga with a comfortable 2-0 victory against Villarreal at the Nou Camp.
Sevilla took full advantage of Barcelona's draw with Atletico Madrid on Saturday to overtake both and go top of La Liga.
Diego Godin battled through injury to score a dramatic late winner as Atletico Madrid beat Athletic Bilbao 3-2 in La Liga on Saturday.
Second-placed Atletico Madrid had to settle for a point in La Liga after conceding a late equaliser in their 1-1 draw at lowly Leganes.
La Liga says it could go to CAS after FIFA president Gianni Infantino rejected its plans to play Spanish league games in the United States.
Eibar ran out 3-2 winners at Girona in La Liga on Saturday, where there was an action-packed end to the first half.
With the January window barely two months away, clubs are finalising strategies for the new year and targets for next summer.
Alaves spurned the chance to join Barcelona and Real Madrid at the top of La Liga after going down 2-1 at Levante on Sunday.
La Liga remains committed to playing Barcelona's league match with Girona next January in Miami, despite opposition.
Alaves missed the chance to join Barcelona and Real Madrid at the top of La Liga as Getafe held them 1-1 at Mendizorroza.
Christian Stuani struck twice to secure Girona a 2-2 draw against Barcelona at the Nou Camp, with the hosts having Clement Lenglet sent off.
FIFA president Gianni Infantino has voiced his objection to leagues playing competitive games abroad.
La Liga says it has requested permission from the Spanish Football Federation to play a regular-season match between Girona and Barcelona in Miami on January 26.
La Liga has announced plans to stage its first overseas fixture, but Sid Lowe feels supporters have been ignored.
Villarreal's difficult start to the La Liga season continued as they were beaten 1-0 at home by Girona on Friday.
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