Kyle Edmund saw his French Open hopes come to an end as he suffered a five-set defeat to Fabio Fognini at Roland Garros.
British No 1 Edmund had never previously faced unpredictable Italian Fognini but was seeded two places higher, as he sought to reach the fourth round in Paris for the first time.
Fognini, a former French Open quarter-finalist, has enjoyed great success on the clay during his career and his greater experience proved pivotal as he won 6-3 4-6 3-6 6-4 6-4.
The world No 18 will next meet third seed Marin Cilic after the big-hitting Croatian secured a comfortable 6-3 6-2 6-4 victory against America's Steve Johnson.
Edmund showed some early steel by recovering from three game points down to break Fognini at the first opportunity, and then saving two break points to take the early initiative.
The Italian 18th seed responded with his first break on his third break-point opportunity in the sixth game, before a second consecutive break enabled Fognini to serve out for the first set.
Edmund was seemingly on the back-foot and under some pressure on his serve, but he broke to love in the fourth game of the second set, while a further break moved the 23-year-old to 5-1.
Fognini had appeared disinterested but he raised his level to break Edmund twice before the Brit returned from receiving medical attention to his left knee to secure the second set to move level on the scoreboard.
Both players improved behind their serve in the third set before a drop in concentration from Fognini, who had earlier received treatment to his left ankle, saw Edmund secure a crucial break of serve in the eighth game. The British No 1 backed it up with a composed service hold to lead two sets to one.
The unpredictable nature of the match continued in the fourth set as Edmund recovered from dropping his opening service game and a 3-0 deficit to get back level, only for Fognini to decisively break in the 10th game to force a decider.
With Fognini serving first, the Italian produced some of his best tennis of the match to save two break points in the fifth game of the set before securing the decisive break in the final game to complete victory and end British hopes in the singles.