South Africa back Jesse Kriel has been ruled out of the rest of the Springboks' European tour after suffering a lower leg injury.
Kriel picked up the injury in the 31-31 draw with the Barbarians at Wembley on Saturday.
The 22-year-old has been replaced in the squad by Lions centre Rohan Janse van Rensburg for the forthcoming Tests against England, Italy and Wales.
South Africa have also drafted in Bulls wing Jamba Ulengo as cover for players who are suffering from minor injuries.
The Springboks' next game is on Saturday when they take on England at Twickenham.
They will then meet Italy in Florence on November 19 and Wales in Cardiff on November 26.