Samu Kerevi has been ruled out of Australia's squad for their tour to Europe next month after undergoing surgery on the ankle.
The 23-year-old suffered the injury in the 37-10 Bledisloe Cup loss to New Zealand on Saturday.
Wallabies coach Michael Cheika announced his 32-man squad on Tuesday, and he has selected three uncapped players including rugby league convert Marika Koroibete.
The Fiji-born Koroibete played for Melbourne Storm in the National Rugby League but has switched to the 15-a-side code and could potentially make his international debut before playing Super Rugby for the Melbourne Rebels.
Hooker Tolu Latu and outside back Kyle Goodwin were the other uncapped players picked in the squad that will attempt to win the Grand Slam - victories at the home grounds of Ireland, Wales, Scotland, and England - for the first time since 1984.
The absence of Kerevi could open the way for Israel Folau to move from fullback to outside centre, where he played for the New South Wales Waratahs last season.
Scrum-half Will Genia has been released by Stade Francais for the tour, meaning he's available for Tests inside the November international window.
Australia open the tour against Wales in Cardiff on November 6 before playing Scotland at Murrayfield on November 13, France in Paris on November 20, Ireland in Dublin on November 27 and wrap up the tour with a Test against England at Twickenham on December 4.
Australia squad: A Alaalatoa, R Arnold, A Coleman, Q Cooper, K Douglas, S Fardy, I Folau, B Foley, N Frisby, W Genia, K Godwin, J Hanson, D Haylett-Petty, R Hodge, M Hooper, S Kepu, M Koroibete, T Kuridrani, T Latu, S McMahon, S Moore (captain), D Mumm, S Naivalu, N Phipps, D Pocock, T Robertson, R Simmons, S Sio, W Skelton, H Speight, J Slipper, L Timani.