Dan Biggar, Taulupe Faletau and Leigh Halfpenny have been declared fit for Wales' Six Nations clash with Ireland in Dublin on Saturday.
The British and Irish Lions trio missed the 12-6 defeat to England at Twickenham on February 10 but have returned to training.
George North, a replacement at Twickenham, and fellow British and Irish Lion Liam Williams are also fit.
Wales forwards coach Robin McBryde said: "Everybody has been given the green light. It's good to have everybody back with a spring in their step and looking forward to Saturday.
"It's nice to have headaches in a few positions and it's always good to have plenty to choose from.
"There's a competitive edge to the squad and it's going to be a tough call on a few individuals I'm sure."
Full-back Halfpenny, who scored two tries in Wales' opening Six Nations win against Scotland, missed the Twickenham defeat after picking up a foot injury.
Fly-half Biggar suffered a shoulder injury playing for the Ospreys in the Champions Cup last month and No 8 Faletau has battled back from damaging knee ligaments.
North and Williams proved their fitness in try-scoring shows for Northampton Saints and Saracens respectively on the weekend.
Winger Josh Adams, who has started the opening two games, also crossed for Worcester.
"The fact we've been there before and had success is something we can draw on," McBryde said.
"But every Six Nations is different, with different players and different circumstances. It's a must-win game for us.
"We just need to find some of the finer details to make sure that ball is being delivered on a plate for our backs."
Wales are unbeaten in their last three matches against Ireland and were 22-9 victors over Joe Schmidt's side in last year's Six Nations.