Ireland head coach Andy Farrell has named his side to face England at the Aviva Stadium in Dublin on Saturday, with Ross Byrne named at fly-half.
With regular captain Jonny Sexton still suspended, Farrell opted for Jack Crowley at No 10 last time out against Italy.
However, for his side's clash with England, Byrne will take the No 10 jersey, James Ryan captaining the side and Crowley moving to the bench.
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Cian Prendergast will make his first Ireland start at No 8 in what is a close to full-strength line-up for the world's top-ranked side, with Farrell calling the Connacht player a "warrior".
Farrell: Prendergast improving all the time
Farrell said of Prendergast: "He's fit, tough. There's all sorts of his game that he needs to tidy up and over the last eight weeks we've seen that in abundance so I'm excited to see him play at the weekend.
"His feel in and around the game has improved, not just decision-making with ball in hand, which has made his skill level a lot better, but also his decision-making defensively.
"He's always been one to chase absolutely everything. His discipline has been something we've needed to talk about from time to time but his all-round game is getting more balance. I just see improvement all the time."
Hugo Keenan comes into the side at full-back, as do Mack Hansen and James Lowe to make up the starting back three.
Bundee Aki and Garry Ringrose are also set for their first appearances of the Bank of Ireland Nations Series in the centres as Stuart McCloskey and Robbie Henshaw drop out.
Andrew Porter, Dan Sheehan and Tadhg Furlong start in the front row, with Tadhg Beirne joining Ryan at lock.
Peter O'Mahony starts at blindside flanker, with Josh van der Flier at openside and Connacht's Prendergast given a huge opportunity to stake his claim for a place in the final 33-player squad, which Farrell is due to name on August 28.
Earls: Hundredth cap would be massive honour
Saturday will be a landmark occasion for Keith Earls, who is in line to win his 100th Test cap should he come off the bench, joining Brian O'Driscoll (133), Ronan O'Gara (128), Cian Healy (124), Rory Best (124), Sexton (113), Paul O'Connell (108), John Hayes (105) and Conor Murray (105) in hitting the milestone.
On potentially earning the honour, Earls said: "I'm trying not to think about it but talking to Andy about if it does happen, he's telling me: 'it's not just another cap, you can't have a normal week because it's not a normal week'.
"It would be a massive honour but also just a bit of relief because I was stuck on 98. I suppose in the last couple of years I was genuinely thinking every time I stepped on to the field it could be the last time. I'd be extremely proud and privileged to join a unique group."
Earls is joined on the bench by Rob Herring, Jeremy Loughman, Finlay Bealham, Joe McCarthy, Caelan Doris, Conor Murray, and Crowley.
Farrell: Injured trio will be back for World Cup
Farrell also insisted that injured Ireland trio Jack Conan (foot), Dave Kilcoyne (hamstring) and Ronan Kelleher (hamstring) will be fit for the World Cup opener against Romania in Bordeaux on September 9.
Farrell added: "Jack is still ongoing. Him, David Kilcoyne and Ronan Kelleher, they're not long-term.
"Whether they're going to be fit for next week for the final warm-up against Samoa, probably not. Will they be fit for the start of the World Cup and available for selection? Definitely, yes."
Ireland side to face England
Starting XV: 15 Hugo Keenan, 14 Mack Hansen, 13 Garry Ringrose, 12 Bundee Aki, 11 James Lowe, 10 Ross Byrne, 9 Jamison Gibson-Park; 1 Andrew Porter, 2 Dan Sheehan, 3 Tadhg Furlong, 4 Tadhg Beirne, 5 James Ryan (C), 6 Peter O'Mahony, 7 Josh van der Flier, 8 Cian Prendergast
Replacements: 16 Rob Herring, 17 Jeremy Loughman, 18 Finlay Bealham,19 Joe McCarthy, 20 Caelan Doris, 21 Conor Murray, 22 Jack Crowley, 23 Keith Earls