Huw Jones says the chance to deny England a landmark win is extra motivation for Scotland ahead of their Twickenham trip.
Victory for Eddie Jones' side in Saturday's Six Nations meeting would see them equal New Zealand's record of 18 straight Test wins - as well as taking them a step closer to a second successive Grand Slam.
The significance is not lost on the Scots, according to centre Jones, who said: "It's a massive opportunity. That's one of the big incentives, to stop their run.
"They have done really well to get to this point but I wouldn't say it's daunting. It's quite exciting to have that opportunity. That is the end goal, we want to win the game, and winning the game will end their run.
"We will be thinking about that, obviously it won't be our sole focus, we will be looking at the tactical side of it and what we can do, it's not just going to be motivational and emotional. But that is what we want to do."
Scotland remain in the hunt for Six Nations honours, with the Triple Crown and the Championship both still on the line.
Last month's defeat of Wales took Vern Cotter's side to a new high of fifth in the world rankings, and Jones said: "As a group, and personally as well, it makes us enormously proud that we have achieved something that hasn't been achieved before.
"It's a big honour and it just shows there are exciting times coming from this squad.
"I think traditionally, not just England, maybe the other teams have even gone into Six Nations thinking that Scotland might be an easy game.
"Over the last couple of years, and this season especially, I think we have managed to change that mind set. I don't think they will be thinking it's going to be an easy game."