Anthony Watson and Mako Vunipola will be released by England to play for Bath and Saracens, respectively, this weekend, as they bid for starting places in their next Six Nations clash against Scotland.
The pair have been named in Eddie Jones' 27-man squad for this week's training camp in Oxford, ahead of the Calcutta Cup contest at Twickenham on March 11.
Exeter centre Henry Slade has been omitted but Bath centre Jonathan Joseph is back after being dropped last week.
Watson returned to England's training squad for last Sunday's win over Italy but did not make the final squad. He will now be given a further opportunity to boost his fitness in Bath's fixture with Wasps on Saturday.
As for Vunipola, who came off the bench against the Azzurri, he will be made available to Saracens for their clash at Newcastle as he seeks to displace Joe Marler at loosehead prop against the Scots.
Four others, Kyle Sinckler of Harlequins, Northampton's Paul Hill, and the Leicester pair of Mike Williams and Ellis Genge, will also be released back to their clubs for this weekend's Premiership fixtures.
Leicester play Exeter on Friday, when Northampton travel to Sale, and Harlequins play at Gloucester this Saturday. The England training camp continues until Friday.
England's 27-man squad
Forwards: J Clifford (Harlequins), D Cole (Leicester), E Genge (Leicester), J George (Saracens), D Hartley (Northampton), J Haskell (Wasps), P Hill (Northampton), N Hughes (Wasps), M Itoje (Saracens), J Launchbury (Wasps), C Lawes (Northampton), J Marler (Harlequins), K Sinckler (Harlequins), M Vunipola (Saracens), M Williams (Leicester), Tom Wood (Northampton)
Backs: M Brown (Harlequins), D Care (Harlequins), E Daly (Wasps), O Farrell (Saracens), G Ford (Bath), J Joseph (Bath), J May (Gloucester), J Nowell (Exeter), B Te'o (Worcester), A Watson (Bath), B Youngs (Leicester)