Ben Te'o will make his first England start against Italy in Sunday's Six Nations game in one of four changes to Eddie Jones' line-up.
The Worcester centre, who represented Samoa at rugby league before switching codes in 2014, replaces Jonathan Joseph for the latest leg of England's Grand Slam pursuit at Twickenham.
It was Te'o's try from the bench against France earlier this month that ensured a winning start for the holders, who are aiming to become the tournament's first back-to-back Grand Slam winners since 1998.
Jones makes two other alterations to the back-line which started the win in Wales, Danny Care taking Ben Youngs' scrum-half spot and Jonny May returning to the right wing in place of Jack Nowell.
The fourth change is in the pack, where James Haskell's improved fitness earns him a recall at the expense of Jack Clifford.
Mako Vunipola is fit enough for a place on the bench after recovering from a knee injury, while Owen Farrell will win his 50th cap at the age of 25.
"We have had a good two-week preparation for Italy and we're ready to go," head coach Jones said. "The boys are really on song, we have had great competition for places, and we've picked a very strong 23 to play against Italy.
"Selection was tough. Ben Te'o at 13 gives us another way of playing the game and we are excited about seeing him, George Ford and Owen Farrell play together in the midfield.
"Ben Youngs has been outstanding for us at number nine, but Danny Care gets the starting jersey this week. For the first half he'll give us a lot of speed and running at the base of the ruck as well as the scrum. Ben will then come on and finish the game.
"Tom Wood has been great for us at seven, and Jack Clifford did well against Wales but James Haskell has the starting role on Sunday; he has come back to a much better level of fitness and we are sure his explosive actions will help us in the first part of the game.
"It is an important Test match for us and our only consideration is to play well. Italy have a proud record in Test rugby, they beat South Africa in November, and we will not underestimate them.
"I know the Twickenham crowd will give Owen Farrell a big cheer. To reach 50 caps at such a young age is a fine achievement. The one thing I know about Owen is that his next 50 are going to be more impressive than his first."
England: 15 Mike Brown, 14 Jonny May, 13 Ben Te'o, 12 Owen Farrell, 11 Elliot Daly, 10 George Ford, 9 Danny Care; 1 Joe Marler, 2 Dylan Hartley, 3 Dan Cole, 4 Joe Launchbury, 5 Courtney Lawes, 6 Maro Itoje, 7 James Haskell, 8 Nathan Hughes.
Replacements: 16 Jamie George, 17 Mako Vunipola, 18 Kyle Sinckler, 19 Tom Wood, 20 Jack Clifford, 21 Ben Youngs, 22 Henry Slade, 23 Jack Nowell.