Eddie Jones named seven uncapped players in England's 37-man training squad ahead of the autumn series.
The Australian will take 37 of a 45-man elite squad for a three-day training camp in Brighton from October 2-4 ahead of the series which involves matches against South Africa, Fiji, Argentina and Australia.
Seven uncapped players are included in the training squad. Second-row Josh Beaumont (Sale Sharks) is named with back row forwards Sam Jones (Wasps), Nathan Hughes (Wasps) and Mike Williams (Leicester Tigers). Scrum-half Dan Robson (Wasps) joins centres Ben Te'o (Worcester Warriors) and Joe Marchant (Harlequins) while Ben Morgan (Gloucester) is also selected for the first time under Jones.
The final squad for the Old Mutual Wealth Series, which gets under way against South Africa at Twickenham on November 12, will be announced on October 26.
Reflecting on his selection, Jones said: "The Old Mutual Wealth Series will be a big challenge and the players will need to step up to the mark. With a number missing through injury it's a good opportunity for others to put their hands up and show us what they're made of.
"I think it's a good situation to be in. Injuries allow us to strengthen the depth of our squad and develop robustness. Ideally, by the Rugby World Cup in 2019, we're looking to have three players in every position who are interchangeable.
"At the moment we have seven of our most influential players not playing regularly for their clubs, but that should be no excuse. England have not beaten South Africa since 2006 and this needs to change.
"In addition to Richard Hill's appointment as team manager earlier this week I am pleased to also announce that Rory Teague will join us in November as a part-time skills coach. He will primarily be working with the players on their individual skills.
"This is a temporary appointment and another good opportunity for an English coach to gain experience and develop their coaching at the highest level."
U20s backs and attack coach Teague was part of the management team which helped guide England to glory at the World Rugby Championships in June.
45-man elite player squad:
Forwards: Josh Beaumont (Sale Sharks), Jack Clifford (Harlequins), Dan Cole (Leicester Tigers), Luke Cowan-Dickie (Exeter Chiefs), Will Evans (Leicester Tigers), Charlie Ewels (Bath Rugby), Ellis Genge (Leicester Tigers), Jamie George (Saracens), Dylan Hartley (Northampton Saints), James Haskell (Wasps), Paul Hill (Northampton Saints), Nathan Hughes (Wasps), Maro Itoje (Saracens),Sam Jones (Wasps),George Kruis (Saracens), Joe Launchbury (Wasps), Courtney Lawes (Northampton Saints), Joe Marler (Harlequins), Matt Mullan (Wasps), Chris Robshaw (Harlequins), Kyle Sinckler (Harlequins), Tommy Taylor (Wasps), Billy Vunipola (Saracens), Mako Vunipola (Saracens), Mike Williams (Leicester Tigers).
Backs: Mike Brown (Harlequins), Danny Care (Harlequins), Elliot Daly (Wasps), Owen Farrell (Saracens), George Ford (Bath Rugby), Alex Goode (Saracens), Mike Haley (Sale Sharks), Jonathan Joseph (Bath Rugby), Alex Lozowski (Saracens), Joe Marchant (Harlequins), Jonny May (Gloucester Rugby), Jack Nowell (Exeter Chiefs), Dan Robson (Wasps), Semesa Rokoduguni (Bath Rugby), Henry Slade (Exeter Chiefs), Ben Spencer (Saracens), Ben Te'o (Worcester Warriors), Manu Tuilagi (Leicester Tigers), Anthony Watson (Bath Rugby), Ben Youngs (Leicester Tigers).
37 players for training camp:
Forwards: Beaumont, Cole, George, Teimana Harrison (Northampton Saints, injury replacement for Haskell), Hartley, Haskell, Hill, Hughes, Itoje, Jones, Kruis, Launchbury, Lawes, Marler, Ben Morgan (Gloucester Rugby), Robshaw, Taylor, Billy Vunipola, Mako Vunipola, Williams.
Backs: Brown, Care, Daly, Ollie Devoto (Exeter Rugby, injury replacement for Manu Tuilagi, Leicester Tigers), Farrell, Ford, Goode, Joseph, Marchant, Nowell, Robson, Rokoduguni, Slade, Te'o, Watson, Marland Yarde (Harlequins, injury replacement for Jonny May), Youngs.