Eddie Jones has branded Ireland "the most cohesive side in the world" and installed Andy Farrell's men as favourites for Saturday's Six Nations showdown at Twickenham.
England head coach Jones attempted to heap the pressure onto Ireland, hinting that their more seamless preparation time carries weight in the autumn and Six Nations Test windows.
But wily Australian coach Jones also warned that those advantages will disappear at the 2023 World Cup in France, with all sides having standardised access to their players in the build-up.
"It's an important week in the tournament, there are three teams left in the tournament and we're lucky enough to be one of those three," said Jones.
"Ireland are favourites for the game, they've been in very good form in the autumn, they're a very settled team, and very well coached by Andy Farrell.
"And, apart from Andrew Porter, I think they've got everybody available and ready to go.
"They are literally, and I say this without any hesitation, the most cohesive side in the world.
"The bulk of their team train together for the bulk of the year.
"So they are very well-coordinated in their attack, they are very structured, they're very sequenced in set plays. And they're tough around the breakdown.
"So that poses a great challenge for us. But we're looking forward to the challenge, we're not intimidated by any team and we're looking forward to playing against them."
Ireland's much-heralded provincial system boosts the Test side through seamless opportunity for players to shift between domestic and international camps.
England's club and country system, while far more joined-up than in times past, still harbours sticking points among the interaction.
And while noting the differences in set-up, England boss Jones insisted any advantages now will evaporate at next year's World Cup.
"We're in a very good position mate, we've got a little over 12 months until we get together for the last part of the project," said Jones.
"The three months before the World Cup is where every team becomes equal.
"We all have the same amount of time to practice, we all have the players the same amount of time.
"Up to now, teams have got their players for differing times, there's different experiences.
"We can only have 25 players until Tuesday, other teams can have 42 until Thursday. So it's all different. But once you get to the World Cup campaign start, it's all equal.
"So how are we tracking now? Yeah, in a really positive manner.
"It's not a perfect straight line, sometimes we're going a bit quicker than others. And sometimes we'd like to go a bit quicker.
"But we've got great spirit in the side.
"Just look at the spine of the team, our 9, 10 and 15 we played against Wales and they've got 12 times, 12 times the amount of caps we've got; 12 times.
"So what a fantastic experience for those young blokes, and to edge out a win against the Six Nations side is a real testament to where they are going.
"How much better are they going to be in 12 months with another 10 caps under their belt?
"The game is evolving and we feel like we're in a really good position to take any opportunities there are to evolve our game in that position.
"And Marcus Smith, Harry Randall and Freddie Steward particularly have added to that mix."
Lynagh out of England squad with Covid
Louis Lynagh will not make his England debut on Saturday after being forced to withdraw from the squad following a positive Covid-19 test.
The 21-year-old back, who is the son of Australia great Michael Lynagh, was part of Jones' extended squad for the match week.
Lynagh, who can play at full-back or on the wing, returned a positive lateral flow test at lunchtime on Monday and immediately went into isolation, before a positive PCR test later confirmed the result.
All of the other England players and staff members have undergone daily lateral flow testing, all of which have returned negative results.
Henderson returns for Ireland
Lock Iain Henderson was ruled out of the Dublin appointment with Italy after testing positive for Covid-19 but will now return to the squad to play England.
But he played the full 80 minutes of Ulster's United Rugby Championship victory over Cardiff on Friday and has been named in a 35-man group by Ireland head coach Andy Farrell.
Munster prop Jeremy Loughman has received his first squad call-up, but Leinster back Jordan Larmour misses out.
The Irish Rugby Football Union said that Larmour was sidelined for the remaining Six Nations games against England and Scotland after suffering a hip injury during Leinster's URC win against Benetton on Saturday.
Jack Carty, Dave Heffernan, Craig Casey, Gavin Coombes, Robert Baloucoune, James Hume and Nick Timoney, meanwhile, all return to the squad after playing for their respective provinces in the latest round of URC action.
Ireland have only beaten England once at Twickenham since 2010, but they need victory to keep the pressure on unbeaten Six Nations leaders France, whose next game is against Wales in Cardiff.
Scotland call up Hastings
Scotland have called up Adam Hastings for Saturday's Six Nations clash with Italy in Rome.
Jonny Gray, Glen Young and Ross Thompson have also joined the squad ahead of the match at the Stadio Olimpico.
Marshall Sykes, Nick Haining, Oli Kebble, Ollie Smith and Rufus McLean have dropped out through injury.
'I don't see any weaknesses in France'
Wales number eight Taulupe Faletau believes the days of France imploding under pressure are gone, with the Six Nations leaders showing a new-found consistency heading into Friday's clash at the Principality Stadium in Cardiff.
The French had a reputation as a side who could fold late on in games, but Faletau says the current squad under coach Fabien Galthie is a much more skilful and resilient selection.
"They've got it all really and that is what you want to play against, the best," Faletau told reporters on Monday. "I don't see any weaknesses in their squad. They will challenge you everywhere.
"We have seen that with the form they are in, the players they have got and how they play. It will be a tough challenge for our defence.
"The France we have seen in the last year or so, there haven't been any implosions, so you have to move away from (thoughts of that) and expect the best France to turn up.
"Friday night is going to be electric in Cardiff, not just the stadium but the whole town."
Faletau has recently returned from a seven-month injury lay-off, but was drafted straight into the Wales squad by coach Wayne Pivac and played in the 23-19 loss to England last time out.
He admits it was a frustrating time on the sidelines due to constant setbacks in his bid to return from an ankle injury sustained on the British & Irish Lions tour of South Africa last year.
"You do get some confidence knowing you have the backing of the staff here, but you have still got to do a job at the weekend and you have to repay the faith they have put in you," Faletau says.
France head the Six Nations table with three wins from three, while holders Wales have one victory so far.