Sky Sports rugby presenter Alex Payne is backing Wales to end France's Grand Slam hopes on Friday.
The Rugby Club host also expects Eddie Jones' England to maintain their unbeaten run but is predicting a 10th straight Six Nations defeat for Scotland in Rome.
England v Ireland (Saturday, 4.50pm)
Recent history stacks up on England's side - winning five of the last six with Ireland, though two of those were rather diluted World Cup warm-ups.
Stretching back even further, England have won eight of the last 11 meetings at Twickenham. Form also favours the home side, as does freshness with the visitors' injury worries dominating their build-up. Having said that, no Joe Schmidt side arrives unprepared and Ireland are more than capable of grabbing a win.
But with seven tries to Ireland's one in the tournament so far I just think England are running in a higher gear, one that should take them home by 6-10 points at 4/1 with Sky Bet.
England's entertainer? Jack Nowell has quietly built up nine tries in his last eight Tests - albeit with a hat-trick in the final world cup game against Uruguay. He is 10/1 to make that 10 this weekend with the first try. For longer odds, Danny Care added real spark when he came off the bench in Rome, he is 18/1 to cross last against Ireland having scored a belter against them at Twickenham in 2014.
Irish inspiration? Ireland have only scored three tries against England in their last six games. Simon Zebo (9/2 anytime) will be tasked with bringing a bit of the X-factor to the Irish side.
Italy v Scotland (Saturday, 2.25pm)
What a bun fight this is set to be. Scotland carried huge amounts of optimism into the tournament off the back of the World Cup, only for it to pop against England. Italy carried huge amounts of optimism into round two off the back of pushing France, only for it to pop against England too.
The Italians pinched last year's Six Nations meeting with a penalty try at the death, and outscored Scotland by three tries to one, but in the head-to-head Scotland have won seven of the last nine.
However, I am going against recent history in this one and think Italy might pinch it. England broke the Italians down physically over 60 minutes and then ran riot in the final quarter but I'm not sure Scotland have the bulk to do the same. I fancy the Azzuri to win by 1-5 points at 11/2 with Sky Bet.
Italian stallion? It's always worth keeping an eye on Sergio Parisse. The only country in the Six Nations the great No 8 hasn't scored a try against is Scotland, but I'm playing Michelle Campagnaro (9/1 anytime) who has been their liveliest back.
Hot Scot? Mark Bennett has scored in his two previous games against the Italians and is 5/2 to make it three in three. Tommy Seymour has scored six tries in his last seven games for Scotland and is also worth considering.
Weekend Sky Bet treble: Wales, Italy and England at 9/2.
Neither side has been terribly convincing so far, but Wales look more capable than France of hitting a higher level this Friday.
Warren Gatland's men hold the cards heading to Cardiff - they are on a four-game winning run over es Blues and boast 660 Test caps in the starting XV, with 292 on the bench.
France have managed just two wins in their last 15 away games, against Scotland and Italy, while their last trip to Cardiff was the All Black quarter-final mauling in the World Cup. Though the team is much changed, I'm not sure the form has.
I'm backing Wales to pick up speed and cruise home by 11-15 points at 9/2 with Sky Bet.
Welsh wonders? George North has scored the first try against France in two the last three meetings, and is 13/2 to score the opening try. At scrum-half Gareth Davies has scored six tries in his last seven Tests which is a sharp return for a nine. Davies is 13/8 anytime.
France firepower? No. They have crossed the whitewash just once against Wales in their last five meetings, so consider no French try at 4/1.
What do you think? Who will win this weekend's matches? Have your say below or Tweet us at: @SkySportsRugby