South Africa-born full-back Scott Spedding will make his France debut against Fiji on Saturday.
The 28-year-old, who became a French citizen earlier this year, was called up by Phillipe Saint-Andre following an injury to Brice Dulin and will wear the No 15 shirt in the Test at Marseille's Stade Velodrome.
Racing Metro backs Alexandre Dumoulin and Teddy Thomas will also make their first appearances for Les Bleus. Dumoulin starts at outside centre alongside Wesley Fofana with Thomas named on the wing.
Saint-Andre has opted for a new half-back partnership in the shape of Toulon scrum-half Sebastien Tillous-Borde and Clermont Auvergne’s Camille Lopez, with former Perpignan teammates Nicolas Mas and Guilhem Guirado linking up with Alexandre Menini in the front row.
Thierry Dusautoir is retained as captain in a back row that also contains South-African-born Bernard Le Roux and Damien Chouly.
Another South African, Castres scrum-half Rory Kockott, has been named among an extended replacements bench that includes Toulon centres Mathieu Bastareaud and Maxime Mermoz.
"It's a very well-balanced team," said Saint-Andre. "Very youthful behind the scrum with a half-back pairing that has two players on top form."
On the subject of foreign-born players being capped by France, which has sparked a lively debate, Saint-Andre was adament.
"For me they are all French. They dream of pulling on the French shirt," he said.
France: 15 Scott Spedding, 14 Yoann Huget, 13 Alexandre Dumoulin, 12 Wesley Fofana, 11 Teddy Thomas, 10 Camille Lopez, 9 Sebastien Tillous-Borde; 1 Alexandre Menini, 2 Guilhem Guirado, 3 Nicolas Mas, 4 Pascal Pape, 5 Yoann Maestri, 6 Thierry Dusautoir (c), 7 Bernard Le Roux, 8 Damien Chouly.
Replacements: (from) Benjamin Kayser, Uini Atonio, Xavier Chiocci, Alexandre Flanquart, Sebastien Vahaamahina, Charles Ollivon, Rory Kockott, Remi Tales, Mathieu Bastareaud, Maxime Mermoz.
Watch France v Fiji live on Sky Sports 2 (red button) from 4.45pm