Scotland's record try-scorer Stuart Hogg will make a first international appearance of the season and Adam Hastings returns to start against Fiji on Saturday.
Alongside the arrivals of Hogg and Hastings, four other new faces are named in the backs. Vice-captain Chris Harris will link up with Cameron Redpath, who is set to earn a first cap at BT Murrayfield, in midfield.
Duhan van der Merwe and Darcy Graham are selected on either wing, with Ali Price continuing at scrum-half.
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Head coach Gregor Townsend has amended two in his pack after the team were narrowly beaten by Australia last weekend. Richie Gray returns to the international fold for a first start since 2017 and George Turner comes in at hooker.
Pierre Schoeman and Zander Fagerson complete the front row while vice-captain Grant Gilchrist joins Gray in the second row.
Jamie Ritchie will lead Scotland as captain from the back row, alongside Hamish Watson and Matt Fagerson. Prop Murphy Walker could make his Scotland debut off the bench.
Elsewhere, Dave Cherry has been replaced in the squad by Fraser Brown after picking up a hamstring injury in training.
"It's a physical challenge," Townsend said about what awaits his side this weekend facing Fiji.
"They're big men, they're the most powerful athletes that we get to play against in rugby. They're very skilful too and we've got to watch out that our accuracy is at its highest level.
"If we're inaccurate with passing, kicking or contact, they're going to make breaks against us. They always get better when they spend time together and I'm sure they've been working hard all week to get their combinations working.
"We know as a group of individuals and as a team, they're very, very dangerous."
"We put in a good performance against Australia," Townsend continued. "We know we had opportunities to win and while we're disappointed, we've got a full squad this week with a lot of competition.
"It's an opportunity for these players to put a marker down," he concluded.
Scotland: 15. Stuart Hogg, 14. Darcy Graham, 13. Chris Harris (vice-captain), 12. Cameron Redpath, 11. Duhan van der Merwe, 10. Adam Hastings, 9. Ali Price, 1. Pierre Schoeman, 2. George Turner, 3. Zander Fagerson, 4. Richie Gray, 5. Grant Gilchrist (vice-captain), 6. Jamie Ritchie (captain) 7. Hamish Watson, 8. Matt Fagerson.
Replacements: 16. Ewan Ashman, 17. Rory Sutherland, 18. Murphy Walker, 19. Jonny Gray, 20. Jack Dempsey, 21. Ben White, 22. Blair Kinghorn, 23. Sione Tuipulotu.
Former Scotland head coach Vern Cotter names three new Fiji caps to face Scots
Fiji coach Vern Cotter is set to hand a debut to three players in their autumn international against his former side Scotland at Murrayfield on Saturday, including 2020 Rugby Sevens Olympic gold medallist Sireli Maqala.
Lock Ratu Leone Rotuisolia will earn a first cap starting in the second row, while utility back Maqala and prop Livai Natave are expected to get a run from the bench.
"[Maqala] has impressed us with his skill sets," Cotter told media. "He can kick well, with the ball he is strong and tough, and he offers us a number of positions as he can play at number 10, 15 and at the centre."
Albert Tuisue has been included at flank, having spent most of his international career to date in the second row, while Viliame Mata returns from injury to take up the No 8 position.
"We are slowly getting together but want to get learnings from this, plus we have the Rugby World Cup next year so it is really important that we put ourselves up against a very good team," Cotter said.
"I'm sure we will come away with individual and collective improvements to be made."
Fiji have beaten Scotland twice in eight meetings, including as recently as 2017 but lost all four of their previous visits to Murrayfield.
Fiji: 15 Kini Murimurivalu, 14 Setareki Tuicuvu, 13 Waisea Nayacalevu, 12 Kalaveti Ravouvou, 11 Vinaya Habosi, 10 Vilimoni Botitu, 9 Frank Lomani; 1 Eroni Mawi, 2 Sam Matavesi, 3 Manasa Saulo, 4 Temo Mayanavanua, 5 Ratu Leone Rotuisolia, 6 Albert Tuisue, 7 Levani Botia, 8 Viliame Mata.
Replacements: 16 Tevita Ikanivere, 17 Livai Natave, 18 Luke Tagi, 19 Apisalome Ratuniyarawa, 20 Kitione Kamikamica, 21 Peni Matawalu, 22 Teti Tela, 23 Sireli Maqala.