Scotland will aim to build on their historic winning start to the 2021 Guinness Six Nations this weekend when they face Wales at BT Murrayfield on Saturday.
Townsend has made three changes, one in the pack and two in the backline following the opening weekend victory over England at Twickenham.
Flanker Jamie Ritchie, centre Cameron Redpath and winger Sean Maitland are unavailable through injury.
Scarlets back-row Blade Thomson and Harlequins centre James Lang come into the starting XV, as does Edinburgh winger Darcy Graham. All three played in the last meeting between the two nations, when Scotland beat Wales in Llanelli in October in the concluding round of the 2020 Six Nations competition.
Captain Stuart Hogg continues at full-back following his man of the match performance in the Calcutta Cup win and he is joined in the back-three by Edinburgh pair Duhan van der Merwe and Darcy Graham.
Rory Sutherland, George Turner and Zander Fagerson pack down in the front row, with Jonny Gray and Scott Cummings continuing their lock partnership.
Thomson comes onto the blindside flank, alongside Hamish Watson and Matt Fagerson in the back-row.
All the replacements who travelled to Twickenham are selected again as the matchday 23.
"We have an opportunity this weekend against Wales to continue the positive start to the Guinness Six Nations we made last week against England," said Townsend.
"It was a very encouraging performance at Twickenham and the squad performed to a level which has to be the benchmark throughout the tournament. Wales are also coming into this game after a win and will have the same objective, so it will be a tough challenge as always.
"Both teams were involved in physical contests last weekend, and that is evidenced by the injuries Wales and we ourselves have picked up. For us, we are able to bring in three quality players in Blade, James and Darcy. They have been training well and are highly motivated to make the most of this opportunity."
Scotland: 15 Stuart Hogg (c), 14 Darcy Graham, 13 Chris Harris, 12 James Lang, 11 Duhan van der Merwe, 10 Finn Russell, 9 Ali Price, 1 Rory Sutherland, 2 George Turner, 3 Zander Fagerson, 4 Scott Cummings, 5 Jonny Gray,
6 Blade Thomson, 7 Hamish Watson, 8 Matt Fagerson
Replacements: 16 David Cherry, 17 Oli Kebble, 18 WP Nel, 19 Richie Gray, 20 Gary Graham, 21 Scott Steele, 22 Jaco van der Walt, 23 Huw Jones