Jonathan Joseph will miss England's tour of South Africa in June as he requires surgery on a foot injury.
The centre suffered the injury to his left foot during Bath's 41-6 loss to Saracens last Sunday and left the field on crutches.
Bath director of rugby Todd Blackadder said: "JJ is going to need surgery to correct his injury. He will then need a lengthy period of time to rehabilitate.
"Our medical team will work closely with him to ensure we get him back on the pitch as soon as possible."
England play three Tests against the Springboks, starting in Johannesburg on June 9, live on Sky Sports.
Joseph, who has won 40 caps, started three of England's five games in this year's Six Nations and came off the bench in the other two.
Worcester's Ben Te'o could start at 13 in Joseph's absence, with Exeter duo Jack Nowell and Henry Slade and Wasps' Elliot Daly also in contention.
Joseph's Bath team-mate Anthony Watson, Courtney Lawes and Nathan Hughes have already been ruled out of the tour, while England captain Dylan Hartley remains sidelined with concussive symptoms.