South Africa have confirmed fly-half Patrick Lambie will miss the deciding third Test against Ireland in Port Elizabeth on Saturday.
Springboks team doctor Konrad von Hagen broke the news that the 25-year-old will miss the last match of the series as he has not recovered from a head injury.
"Patrick is still experiencing symptoms of concussion and will not be available for selection," Von Hagen said.
Lambie was concussed in an aerial collision with Irish flanker CJ Stander during the first Test and missed the second, which the Springboks won to level the series.
Stander was red-carded after the incident but will be available for the Test at Nelson Mandela Bay Stadium having served a one-match suspension.
Elton Jantjies deputised for Lambie in the second Test, which South Africa won 32-26 in Johannesburg thanks to a dramatic comeback in the last-quarter.
Prop Trevor Nyakane (ankle) and loose forwards Duane Vermeulen (elbow) and Warren Whiteley (shoulder) will have scans to determine the extent of injuries sustained in the second international.
Lood de Jager, who missed the Test because of a calf strain, is receiving physiotherapy and the lock could be available for Port Elizabeth.