Long-time 1000 Guineas favourite Inspiral has been ruled out of Sunday's Classic at Newmarket after missing some crucial preparation, with the Coronation Stakes at Royal Ascot now the main aim.
The John and Thady Gosden-trained filly failed to make an intended racecourse gallop, leading connections to delay her highly-anticipated first start as a three-year-old.
Inspiral, owned by Cheveley Park Stud, was unbeaten in four juvenile starts, progressing from a Newmarket maiden in July, to Listed success at Sandown and then Group Two glory in the May Hill Stakes at Doncaster.
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She finished her 2021 campaign with victory in the Group One Fillies' Mile, but her not run since that October outing.
Chris Richardson, managing director to owners Cheveley Park Stud, said: "John Gosden had an in-depth discussion with the boss, Mrs Thompson, and following that it was decided that sadly she would miss the 1000 Guineas.
"John Gosden feels she wasn't really ready for the race and when you receive that advice from a trainer such as John, you follow it and now we'll look to the Coronation Stakes at Royal Ascot as part of her programme.
"It is disappointing for all concerned but we must heed their advice.
"Royal Ascot is a favoured meeting of the Thompsons and we've had success there previously, it's the start of the year and we've still got lots of opportunities going forward."
Aidan O'Brien's Tenebrism, winner of last year's Group One Cheveley Park Stakes, is the new 5/2 favourite (Sky Bet), ahead of Jessica Harrington's Moyglare Stud Stakes winner Discoveries (6/1).