Rookie quarterback Carson Wentz enjoyed a stellar NFL debut as he upstaged Cleveland's Robert Griffin III in the Philadelphia Eagles' 29-10 win over the Cleveland Browns on Sunday.
Wentz, who was promoted from No 3 quarterback to starter last Monday, completed 22 of 37 passes for 278 yards, two touchdowns and no interceptions to look every bit the franchise quarterback the Eagles were hoping for when they drafted him with the No 2 overall pick in April.
"I wasn't really nervous. I really don't get nervous," Wentz said. "I had a lot of fun today and the turnout was good."
In Seattle, Russell Wilson threw a two-yard touchdown pass to Doug Baldwin with 31 seconds remaining to give the Seattle Seahawks a dramatic 12-10 win over the Miami Dolphins.
The Dolphins, who had Kenny Stills drop a certain touchdown pass while wide open in the second quarter, looked to be heading to a shock win in the north west in Adam Gase's first game in charge before Wilson connected with Baldwin at the last.
Kicker Wil Lutz missed a 61-yard field goal attempt in the dying seconds as the New Orleans Saints were beaten 35-34 by the Oakland Raiders.
The Raiders scored 22 points in the fourth quarter, edging in front with Michael Crabtree's two-point conversion, and although the Saints made good progress upfield, rookie kicker Lutz put his game-winning attempt wide of the left-hand upright.
The Kansas City Chiefs produced the largest second-half comeback in franchise history as they claimed a 33-27 overtime win against the San Diego Chargers.
The Chiefs were 24-10 down going into the fourth quarter, but touchdowns from Jeremy Maclin and Spencer Ware helped to force overtime.
Quarterback Alex Smith then took matters into his own hands to run in the winning score for the home side.
Earlier, Melvin Gordon had put the Chargers in control with the first touchdowns of his NFL career. Big things were expected of running back Gordon when he was selected 15th overall in the 2015 draft, but he failed to score once during his rookie season.
His first NFL touchdown arrived in the first quarter from a yard out and he then followed that in the second with a six-yard run, but it was all to no avail.
Joe Flacco and Mike Wallace combined for a 66-yard touchdown as the Baltimore Ravens battled to a 13-7 win against the Buffalo Bills, while a stunning 54-yard touchdown from the impressive AJ Green helped the Cincinnati Bengals to a narrow 23-22 success against the New York Jets.
The Chicago Bears slipped to a 23-14 defeat to the Houston Texans in their opener, with rookie Will Fuller's fourth-quarter touchdown proving decisive.
A stunning touchdown catch from Austin Seferian-Jenkins helped the Tampa Bay Buccaneers to a 31-24 win over the Atlanta Falcons, while the Green Bay Packers held on for a 27-23 win against the Jacksonville Jaguars, with Jordy Nelson scoring a rare touchdown.
Meanwhile, Matt Prater atoned for an earlier miss with a 43-yard field goal with eight seconds remaining to edge the Detroit Lions to a wild 39-35 win over the Indianapolis Colts.
And the Minnesota Vikings recovered from a scoreless first half to claim a 25-16 victory against the Tennessee Titans, with Eric Kendricks' 77-yard interception return the pick of the scores.