Ryder Hesjedal will join Trek Factory Racing from Cannondale-Garmin in 2016.
The 34-year-old Canadian has signed a one-year deal with the American team.
Hesjedal won the 2012 Giro d'Italia and proved he is still a grand tour contender by finishing fifth in this year's edition.
His exit brings to an end an eight-year stay with the Garmin set-up, having been one of the team's founding members in 2008.
Hesjedal said: "I am very excited about this. Trek's management and I are on the same page in terms of what we can achieve together. I know that I still have podium level legs for the grand tours. The Ardennes Classics will be important as well. You basically work backwards with the Giro being the No 1 goal."
Trek Factory Racing general manager Luca Guercilena added: "This is an excellent signing for our team and I have no doubt our fans in North America will be very happy as well. Ryder is a very strong racer and he has a very constant performance. Welcoming a grand tour winner makes us feel very proud. I believe he will be a good fit for our team."