Liverpool, Chelsea and Manchester City have avoided each other in the FA Cup quarter-final draw.
Chelsea will travel to Middlesbrough, who have already knocked out Tottenham and Manchester United in successive rounds.
Southampton will host Manchester City and Liverpool will play Nottingham Forest after they beat Huddersfield Town on Monday, with Steve Cooper's side having already knocked out the two most recent FA Cup winners in Leicester City and Arsenal.
Crystal Palace will play Everton in the other tie after Frank Lampard's side beat non-League Boreham Wood 2-0 thanks to two goals from Salomon Rondon.
The ties will be played between Friday, March 18 and Monday, March 21.
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FA Cup quarter-final draw in full
Middlesbrough vs Chelsea
Southampton vs Manchester City
Crystal Palace vs Everton
Nottingham Forest vs Liverpool