Tottenham are boosted by the return of Toby Alderweireld, Mousa Dembele and Vincent Janssen for Wednesday's Premier League clash at Southampton, live on Sky Sports 1 HD from 7.30pm.
Spurs, currently in fifth, are the last of the top-four contenders to play after Christmas, with Mauricio Pochettino returning to his former club as he looks to remain in touch of the Champions League places.
Southampton, unbeaten in their last four games in all competitions, haven't conceded a home goal in five hours and five minutes of Premier League football.
Southampton's 2-1 win over Spurs in May ended a run of seven Premier League games without beating them. Another victory would see Claude Puel's men move to within six points of their opponents.
Team news
Jordy Clasie has picked up a groin injury and will not feature against the north Londoners.
"It's a pity that Clasie has a groin pain and this is a difficulty for us," Saints boss Puel said.
Spurs boss Pochettino has almost a full squad to choose from, with Alderweireld (back), Janssen (ankle) and Dembele (knock) available for selection after sitting last weekend's victory over Burnley out.
Opta stats
After six successive away defeats to the Saints in all competitions, Tottenham are unbeaten in their last four games against them on the south coast (W3 D1).
Pochettino took charge of Southampton 54 times in the Premier League and won 35 per cent of his matches there (19).
Southampton's 17 Premier League games this season have seen just 33 goals scored; fewer than any other side.
Only Chelsea (43) have allowed their opponents fewer shots on target than Southampton (45) in the Premier League this season.
Tottenham (111) are one of only two sides to have attempted 100+ shots on target in the Premier League this season, alongside Liverpool.
Since joining Southampton in August 2014, Fraser Forster has kept a clean sheet in 40 per cent of his Premier League matches for the club (26/65) and conceded only 54 goals.
Harry Kane has scored with just two of his 17 shots in the Premier League since November 26 and one of those goals was a penalty.
Merson's predictions
Spurs have got a hard Christmas schedule. If they come through this period with some positive results, they will be well in the mix. Southampton are another team crying out for a bit of consistency. They were comfortable in the end against Bournemouth and it was good to see Jay Rodriguez back among the goals but I'm not sure about them. I fancy Spurs to win at St. Mary's, draws are simply no good to them.
PAUL PREDICTS: 1-2 (Sky Bet odds 9/1)
Betting
Tottenham are 6/4 favourites to make it three Premier League wins in a row when they travel to Southampton on Wednesday evening, with the home side 15/8 to take the three points and the draw 9/4. Spurs are 9/4 to win 1-0, 2-0 or 2-1. Christian Eriksen has been in good form recently and can be backed at 15/2 to score the first goal, but it's Harry Kane who still heads the market at 9/2 from Southampton pair Jay Rodriguez (11/2) and Shane Long (6/1). It's 17/2 to end goalless at St Mary's.
Watch Southampton v Tottenham live on December 28 from 7.30pm, Sky Sports 1 HD. Sky Q 2TB customers can watch the game in Ultra HD. Visit sky.mnosports.com/uhd for details.