West Ham could set a Premier League first with victory over Manchester United at Old Trafford on Saturday.
No team has ever won at Arsenal, Liverpool, Manchester City and United in the same Premier League season, but the Hammers are three quarters of the way there.
They also beat champions Chelsea in late October, although their form has dipped since that result, with two defeats and two draws in their last four games.
United have drawn their last two matches against PSV Eindhoven and Leicester and their playing style has continued to come under scrutiny.
However, they start the weekend just one point behind league leaders City and face three sides in the bottom half of the table before Christmas.
Team news
Wayne Rooney misses out for United due to an ankle injury and defender Marcos Rojo is also unavailable after dislocating his shoulder in training.
Phil Jones and Ander Herrera have not overcome the ankle and hamstring injuries they suffered at Watford a fortnight ago while Luke Shaw (leg) and Antonio Valencia (foot) are also out, but Jesse Lingard has recovered from a hamstring injury.
Andy Carroll is set to start for West Ham after Diafra Sakho was ruled out for around three months with a thigh injury sustained against West Brom last Sunday.
Sakho joins Dimitri Payet and Enner Valencia (both ankle) on the sidelines but skipper Mark Noble and defender James Collins are available after completing suspensions.
Opta stats
United are unbeaten in their last 13 Premier League meetings with West Ham, winning 11 and drawing two.
West Ham have lost seven successive Premier League games at Old Trafford and have won only twice there in the Premier League era (W2 D0 L17).
Indeed, of teams United have faced 10+ times at Old Trafford, the hosts' best Premier League points-per-game rate has come against West Ham (2.70).
Mauro Zarate has scored in three of his four Premier League starts for West Ham in 2015-16.
The Red Devils have lost just two Premier League home games in 2015, a joint-league-low along with Arsenal and Tottenham.
Merson's predictions
It's unusual for me but I'm siding with Manchester United!
They aren't playing well but they just don't lose. There's certainly something about Louis van Gaal's side.
I'm going for a 2-0 United win because West Ham have hit a bit of a brick wall after their brilliant early season form.
PAUL PREDICTS: 2-0 (5/1 with Sky Bet)
Betting
Manchester United are 4/9 with Sky Bet to continue their solid home form this season with three points against West Ham (13/2). United have conceded only one goal in five top flight games and are 11/8 to win to nil.
West Ham have impressed on their travels with victories at Manchester City, Arsenal and Liverpool but have secured only two from a possible 12 points recently. Both sides drew 1-1 last week and it's 13/2 for a repeat of that scoreline, while United to win by exactly one goal is 5/2.
Anthony Martial is 7/2 to open the scoring with Diafra Sakho a 7/2 shot to net anytime for the visitors. Soccer Saturday tipster Matt Le Tissier is backing the Red Devils to win 2-0 at odds of 5/1 with Sky Bet. See all the odds here.