Wayne Rooney will be reunited with Man Utd in the FA Cup fifth round, while Chelsea will host Liverpool.
Rooney's Derby saw off Northampton in an FA Cup fourth-round replay and will welcome 12-time winners United to Pride Park.
Liverpool's youngsters edged Shrewsbury in their own replay to book a date with Chelsea in a repeat of the 2012 FA Cup final.
Manchester City, who won the trophy last year with a 6-0 thrashing of Watford, will travel to Championship side Sheffield Wednesday.
Tottenham or Southampton, who face a replay in north London, will host Norwich, while Leicester will host Birmingham.
Championship leaders West Brom have been handed a home tie against Newcastle, while Reading will host Sheffield United.
The fifth-round fixtures will take place in the week commencing Monday, March 2. The FA have scrapped replays should any of the fifth-round games be drawn as part of their commitment to a winter break in February for Premier League sides.
Revised FA Cup fifth-round draw
Sheffield Wednesday vs Manchester City
Reading vs Sheffield United
Chelsea vs Liverpool
West Brom vs Newcastle
Leicester vs Birmingham
Derby vs Manchester United
Southampton/Tottenham vs Norwich
Portsmouth vs Arsenal
FA Cup key dates
Fifth round: March 2-5
Quarter-final: Saturday March 21
Semi-final: Saturday April 18/19
Final: Saturday May 23