It's MLS Rivalry Week and Sky Sports are showing five live games this weekend, starting with New York Red Bulls v New York City FC.
The New York rivals clash at the Red Bull Arena in the 10th Hudson River derby and it's live on Sky Sports Football at midnight on Saturday.
With the play-offs just around the corner, NYCFC still have faint hopes of catching league leaders Toronto but the Red Bulls would love nothing more than to derail their cross-city rivals.
David Villa will be leading the line for the visitors and the Spaniard is in with a genuine chance of setting a new record for the number of goals scored in a single MLS campaign.
With nine games of the regular season remaining, he is just eight goals off the current total of 27 - reached previously by three players including former Manchester City forward Bradley-Wright-Phillips, who will be on the opposite side on Saturday.
Villa is again the dangerman for NYCFC and his recent run of form has seen him score in four of New York City's last five games, including his first hat-trick in America against New York Red Bulls earlier this month.
Next up, Orlando City take host the Vancouver Whitecaps at Orlando City Stadium, live on Sky Sports Football at 12.30am on Sunday.
Both teams are fighting for play-off qualification in their respective conferences, so the stakes will be high.
Following that is Montreal Impact and Toronto FC, known as the 401 derby.
Toronto lead the way for wins in this derby - which gets its name from the Ontario Highway 401 that connects the two cities - with 17 wins to Montreal's nine in 36 matches. They also boast the two top scorer's in the fixture's history in their squad in Jozy Altidore (8) and Sebastian Giovinco (6).
And there's plenty riding on this encounter with Toronto, who have a first Supporters' Shield within their grasp, chasing history. Greg Vanney's side are closing in on a number of MLS records, including most points, most points per game, most goals, biggest goal differential, and more.
Rivalry Week continues with one of the oldest rivalries in the MLS as LA Galaxy take on rivals San Jose Earthquakes in what is known as the California Clasico.
San Jose currently find themselves on the edge of the play-offs but they have a real opportunity of forcing their way in, starting with a win against their rivals at the StubHub Centre.
However, struggling five-time champions Galaxy, who were beaten 2-0 by Columbus Crew on Thursday, will be hoping to spoil the party, live on Sky Sports Football at 12.10am on Monday.
Finally, Rivalry Week is brought to a close by on of the biggest rivalries in the MLS.
MLS Cup champions Seattle Sounders host Portland Timbers - live on Sky Sports Football at 2.30am on Monday - and both teams right in the thick of things at in the Western Conference.
Locked on 37 points apiece, a win for either side would be a huge boost with race for the play-offs pick up pace.
Watch MLS Rivalry Week live on Sky Sports, starting with New York Red Bulls v New York City FC on Sky Sports Football at midnight on Saturday morning.