Servando Carrasco's first-half header was enough for Orlando City to beat the New York Red Bulls 1-0 on Sunday.
Carrasco headed home in the 34th minute as Orlando eventually made some sustained pressure pay.
Bradley Wright-Phillips squandered late chances to level as Orlando hung on for a third win from their opening four fixtures.
Sporting Kansas City found their goalscoring touch in a 3-1 win over the Colorado Rapids.
Scoring more goals in one match than they had in their first four combined, Sporting took control through Seth Sinovic's early strike before second-half goals from Gerso Fernandes and Dominic Dwyer.
Kevin Doyle pulled a goal back for the visitors from the penalty spot deep into stoppage time.