Arsenal midfielder Granit Xhaka and Manchester City defender Eric Garcia were both stretchered off on the opening evening of the Premier League restart.
Xhaka appeared to collide with team-mate Matteo Guendouzi and was stretchered off the pitch, with Dani Ceballos his replacement.
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Moments later, Spanish centre-back Mari signalled a problem with his Achilles after tracking a run by Riyad Mahrez and was replaced by David Luiz on 23 minutes.
Luiz was then sent off in the 49th minute after conceding a penalty for City's second goal.
With 10 minutes remaining, City goalkeeper Ederson clattered into the back of defender Garcia as he was attempting to clear the ball. It resulted in a stoppage for around eight minutes with Garcia being stretchered off.
City boss Pep Guardiola said after the match: "Eric had a fantastic game, he did really well and he was composed. It was sad to see him go off like that.
"At first he looked pretty bad but after a little bit he looked himself; but only time will tell. He was conscious, he may have to go to the hospital for extra tests."
Watch the Premier League live on Sky Sports
- 64 live games on Sky Sports from restart date of June 17
- 25 games to be made freely available
- New Sky Sports digital innovations also planned to enhance fan experience
- Watch 39 Premier League & 45 EFL games exclusively live
The Premier League 2019/20 season will provisionally restart on Wednesday June 17 and Sky, the UK's leading football broadcaster, will make 25 games available 'free to air' - including Everton vs Liverpool on the first full weekend back - for everyone in the UK to enjoy.