Chelsea striker Diego Costa has been withdrawn from Spain's squad to face England on Tuesday due to injury.
Spain have called up former Liverpool forward Iago Aspas in place of Costa, who will also miss his nation's World Cup Qualifier against Macedonia on Saturday, live on Sky Sports 1 via the Red Button from 7.45pm.
A statement from Spain said Costa arrived in Madrid earlier this week to join up with the squad and immediately underwent medical tests to ascertain the full extent of the injury, but did not play any part in training on Wednesday.
Costa has been in excellent form for Chelsea, scoring nine goals in nine Premier League games for Antonio Conte's side, and scored in Spain's last World Cup Qualifier - a 2-0 win over Albania.
Chelsea have a number of tough top-flight fixtures coming up, with their next Premier League match against Middlesbrough on November 20, live on Sky Sports 1, followed by a local derby against rivals Tottenham Hotspur and a trip to play Pep Guardiola's Manchester City.
Conte's Chelsea have the most players away on international duty of any Premier League side during the current break, with 20 players having been selected to play for their countries.
The Blues can equal the Premier League record for consecutive clean-sheet wins, set by Manchester United in the 2008/09 season, if they win their next four matches without conceding.