Germany's Jerome Boateng has been ruled out of the friendly against England at Wembley on Friday.
The Bayern Munich defender has been nursing unspecified muscle problems, the German football association said in a statement, and would miss the game as a precautionary measure after a discussion with head coach Joachim Loew.
It has not yet been decided if he will play in Tuesday's friendly against France in Cologne.
Midfielder Toni Kroos is a doubt for the England game after missing training on Wednesday with a stomach virus.
England's preparations for the friendly have been affected by injuries, with Harry Kane, Raheem Sterling and Jordan Henderson among a number of players missing from the squad.
Reigning world champions Germany, who topped their World Cup qualifying group with ten wins out of ten matches, are strongly fancied to defend their title in Russia next year.