Wales players on World Cup duty will be allowed to leave the camp to complete transfers before the transfer window shuts.
Chris Coleman's squad met on Monday ahead of qualifiers against Austria and Moldova, which could have a big impact on whether Wales - currently third in Group D - reach the finals in Russia next year.
But Coleman insists he will not stand in the way of any of his players looking to complete a late switch before Thursday's 11pm deadline.
"Twenty-four hours in football is a long time," Coleman said, when asked if Joe Ledley would be given permission to complete a Deadline Day transfer while on Wales duty. "Who's to say a club might say we've got a better offer now?
"I've had that as a manager myself. A player stalled, I waited and ended up with a better offer of a better player.
"If there's something there for you as a player, you have to go and take it."
Ledley is still without a team after leaving Crystal Palace in June and could therefore sign for a club after the window closes, but Coleman will still free the midfielder up to make a late journey to an interested club.
"I wouldn't begrudge Joe travelling anywhere if it was for a move he wanted," Coleman added.
Coleman had experience of such upheaval 12 months ago when the transfer window fell in the week of the opening 2018 World Cup qualifier at home to Moldova.
Hal Robson-Kanu left Wales' base in the Vale of Glamorgan to complete a transfer to West Brom.
"It is disruptive, but what can you say if it's for the good of the player?" Coleman said.
"I couldn't say to Hal 'You can't go there, you have to come here with us because we've got a meeting.'
"Let's say he misses out on that West Brom deal - what are you going to get out of that?
"For the sake of a night, it's not a big deal. Luckily most of our players know our plan."
Wales are assessing the fitness of Aaron Ramsey after the midfielder suffered a kick to his calf in Arsenal's 4-0 Premier League defeat at Liverpool on Sunday.
Ramsey came in for heavy criticism for failing to protect the Arsenal defence at Anfield and was withdrawn at half-time.
Wales already have issues in midfield for the Austria game as they seek to close the four-point gap on Group D front-runners Serbia and the Republic of Ireland.
Joe Allen is suspended, Emyr Huws is out with an Achilles problem and Ledley has not played a club game for nearly seven months.
Leicester's Andy King and David Edwards, who left Wolves to join Reading last weekend, have also had limited game-time this season.